{"id":"W4415644560","doi":"10.1101/2025.10.28.685111","title":"Pantetheinamides that inhibit the growth of intracellular <i>Salmonella</i> Typhimurium","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University; McGill University","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research","keywords":"Intracellular; Biosynthesis; Cofactor; Mode of action; Bacteria; Host (biology); Mutant; Metabolic activity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007388378,0.0003124516,0.000144846,0.0001415369,0.00008502207,0.000174066,0.0001499144,0.0001938906,0.001852866],"category_scores_gemma":[0.00006255473,0.00009711772,0.0001402395,0.00009967697,0.0001184407,0.0001031269,0.0001648088,0.0002661278,0.0003403495],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001628021,"about_ca_system_score_gemma":0.0001505841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00042885,"about_ca_topic_score_gemma":0.0009508061,"domain_scores_codex":[0.9999548,0.000007316002,0.000004275289,0.000009395052,0.00001069468,0.00001339347],"domain_scores_gemma":[0.9999759,0.000004243524,0.000006015713,0.000002950198,0.000004632589,0.000006327803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001373944,0.00003273637,0.00008510365,0.00006461317,0.000004494762,0.00003614119,0.000008571564,0.0001614765,0.9955056,0.0001079368,0.0001156349,0.003740212],"study_design_scores_gemma":[0.0000348301,0.0009160225,0.0009787463,0.000008621408,0.00001047172,0.0001460471,0.00001438901,0.0003312214,0.9936558,0.00004547343,0.003854095,0.000004423613],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986398,0.00223108,0.003262101,0.0002026288,0.00004447095,0.00008218978,0.000745578,0.0001827426,0.006851207],"genre_scores_gemma":[0.98896,0.001737054,0.003852935,0.0001051251,0.000007938119,0.00004220387,0.0007419378,0.00002199872,0.004530885],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001852866,"threshold_uncertainty_score":0.006198466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02109691994998645,"score_gpt":0.2203531302547605,"score_spread":0.1992562103047741,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}