{"id":"W4415651249","doi":"10.1038/s41421-025-00837-6","title":"LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation","year":2025,"lang":"en","type":"article","venue":"Cell Discovery","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"SKiN Health","funders":"National Natural Science Foundation of China","keywords":"Regulator; Transcription (linguistics); Ubiquitin ligase; Biogenesis; Transcription factor; Downregulation and upregulation; Inflammation; Ribosome biogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001727915,0.0003781238,0.000447079,0.0002890198,0.0003521449,0.00006547176,0.0004738453,0.0005399974,0.0004347063],"category_scores_gemma":[0.00003229595,0.0003284713,0.000191743,0.0003152337,0.0001951888,0.0003760946,0.00038231,0.0004287094,0.001677556],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009409897,"about_ca_system_score_gemma":0.00009580837,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001549499,"about_ca_topic_score_gemma":0.000009155145,"domain_scores_codex":[0.9979027,0.0002328129,0.0004739502,0.000695086,0.00005779723,0.0006376702],"domain_scores_gemma":[0.9988276,0.0001878318,0.0001639435,0.000711474,0.00007171308,0.00003744356],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004569309,0.0003130982,0.0001188306,0.00005077849,0.00007871419,0.000004447539,0.0002680906,0.000272123,0.9811171,0.0002419508,0.01490304,0.002174854],"study_design_scores_gemma":[0.001263321,0.0001457655,0.0005275304,0.0001196775,0.00004608815,0.000003937995,0.0001509822,0.00001447628,0.9472598,0.001107564,0.04901797,0.0003429268],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825981,0.0009975111,0.005815117,0.0004517515,0.003042302,0.0004900687,0.00004259943,0.0001557661,0.006406745],"genre_scores_gemma":[0.9009035,0.0000950137,0.0001297353,0.0006112298,0.00007200732,0.00004475336,0.0001834938,0.00003178001,0.09792852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09152178,"threshold_uncertainty_score":0.9999167,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006073196196330463,"score_gpt":0.2112184181136541,"score_spread":0.2051452219173236,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}