{"id":"W4415656346","doi":"10.1038/s41588-025-02368-y","title":"Cell-type- and locus-specific epigenetic editing of memory expression","year":2025,"lang":"en","type":"article","venue":"Nature Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Epigenetics; Epigenesis; Engram; Epigenetic regulation of neurogenesis; Regulator; Master regulator; Regulation of gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002593411,0.0003018081,0.0002580131,0.0002257667,0.0001199285,0.0004490155,0.0004422514,0.0002435682,0.002008116],"category_scores_gemma":[0.0002912118,0.0001356387,0.0002614096,0.0001158769,0.0004351825,0.0002950125,0.0006353587,0.0007356728,0.0004980025],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001931826,"about_ca_system_score_gemma":0.0001612339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001834138,"about_ca_topic_score_gemma":0.0004174809,"domain_scores_codex":[0.9997739,0.00001669923,0.00001722249,0.00008916594,0.00006112794,0.00004177888],"domain_scores_gemma":[0.9997062,0.00006146653,0.00009464187,0.00008247131,0.00002199802,0.00003315585],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001982593,0.00001152024,0.0001394986,0.00002319547,0.000004720911,0.00003525379,0.00001129518,0.0001015655,0.995976,0.0006299944,0.00002881258,0.003018218],"study_design_scores_gemma":[0.000003108715,0.00005419935,0.0009120771,0.00000348304,0.000009233042,0.0001295537,0.000008139984,0.0008238578,0.9957338,0.0001697935,0.002149243,0.000003554783],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8787984,0.002233889,0.1067678,0.0002730954,0.0002623514,0.0000844543,0.0007796373,0.001325186,0.009475322],"genre_scores_gemma":[0.9836511,0.0004684129,0.01108853,0.0000828415,0.000024428,0.00003364541,0.0002442168,0.0001827243,0.004224133],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002008116,"threshold_uncertainty_score":0.006717801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003453597764858766,"score_gpt":0.2672373500475715,"score_spread":0.2637837522827128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}