{"id":"W4415660903","doi":"10.1186/s10020-025-01355-7","title":"Platelets induce epithelial to mesenchymal transition in renal proximal tubular epithelial cells through TGF-β signaling pathway","year":2025,"lang":"en","type":"article","venue":"Molecular Medicine","topic":"Chronic Kidney Disease and Diabetes","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Direktorat Jenderal Pendidikan Tinggi; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi; ZonMw; Fundação de Amparo à Pesquisa do Estado de São Paulo","keywords":"Epithelial–mesenchymal transition; Platelet; Kidney; Cell cycle; Fibrosis; Paracrine signalling; Kidney disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000142319,0.0002238407,0.0002456443,0.0002418106,0.0001609512,0.0002924281,0.0001323673,0.0002121856,0.001658418],"category_scores_gemma":[0.00009348523,0.0001193927,0.000456639,0.0001939811,0.0001420548,0.0001689209,0.0002049309,0.000846861,0.0004005783],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001635693,"about_ca_system_score_gemma":0.0002792378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000420859,"about_ca_topic_score_gemma":0.0006967391,"domain_scores_codex":[0.9998417,0.00003092353,0.00002008153,0.00001777388,0.00004922108,0.00004039201],"domain_scores_gemma":[0.9999243,0.00001315162,0.00002110714,0.000008697152,0.00001420713,0.000018606],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006438468,0.0002689813,0.000624684,0.0002685735,0.00002811741,0.0001953636,0.00008079188,0.0002067296,0.9919611,0.000288921,0.000435645,0.004997175],"study_design_scores_gemma":[0.000175888,0.001988205,0.0106337,0.0000418355,0.00008380624,0.0004945283,0.0001318927,0.002142891,0.9750434,0.000220051,0.009033229,0.00001057037],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864617,0.005478349,0.003025596,0.0003506096,0.0001016996,0.0000830939,0.0005488931,0.0001162019,0.003833689],"genre_scores_gemma":[0.991807,0.002666881,0.00148318,0.0001843804,0.00003233446,0.0001207025,0.0007270923,0.00001199294,0.002966458],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001658418,"threshold_uncertainty_score":0.005547941,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001612260914275,"score_gpt":0.2634752692129796,"score_spread":0.2534591466038369,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}