{"id":"W4415667116","doi":"10.1038/s44318-025-00620-z","title":"DNGR-1 signalling limits dendritic cell activation for optimal antigen cross-presentation","year":2025,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"HORIZON EUROPE European Research Council; HORIZON EUROPE Marie Sklodowska-Curie Actions; Medical Research Council; UK Research and Innovation; Boehringer Ingelheim Fonds; European Commission; Cancer Research UK; Wellcome Trust","keywords":"Receptor; Immune system; Innate immune system; Signalling; Dendritic cell; Signal transducing adaptor protein; Antigen; Phosphatase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006266853,0.0001291683,0.0001601991,0.0001294846,0.001050785,0.0001315532,0.0003205249,0.000117142,0.0002351764],"category_scores_gemma":[0.0001319546,0.00009336411,0.0001501499,0.0001245963,0.0001280125,0.0002252262,0.00002446867,0.000378788,0.00005574455],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004528591,"about_ca_system_score_gemma":0.000139266,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001069245,"about_ca_topic_score_gemma":6.394823e-7,"domain_scores_codex":[0.9989191,0.0002877649,0.0003254498,0.0001245809,0.00003765693,0.0003054294],"domain_scores_gemma":[0.9988852,0.0006239904,0.0001669836,0.0001492776,0.0001651346,0.000009398945],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001618358,0.00007906352,0.0004456484,0.0000151524,0.0002185316,0.000001167691,0.0006900456,0.000889335,0.9877439,0.0003139129,0.003125897,0.004859043],"study_design_scores_gemma":[0.002252957,0.0001746457,0.006746947,0.0000834727,0.00004714259,0.00009466371,0.0005294383,0.0001534078,0.9631659,0.0008373727,0.02578769,0.0001262927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9646745,0.005916802,0.02648196,0.0009891641,0.001046791,0.0002796786,0.000004338207,0.00003714786,0.0005696428],"genre_scores_gemma":[0.9873616,0.0004525416,0.0002836227,0.0004327264,0.00007976056,0.00001883586,0.0000202273,0.00001439243,0.01133632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02619833,"threshold_uncertainty_score":0.8081895,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02020216055982297,"score_gpt":0.3072354440903194,"score_spread":0.2870332835304964,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}