{"id":"W4415668960","doi":"10.1016/j.htct.2025.104824","title":"DARATUMUMAB PLUS BORTEZOMIB, LENALIDOMIDE, AND DEXAMETHASONE (DVRD) IN PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA (NDMM): SUBGROUP ANALYSIS OF TRANSPLANT- INELIGIBLE (TIE) PATIENTS IN THE PHASE 3 CEPHEUS STUDY","year":2025,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Multiple Myeloma Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Alberta; University of Calgary","funders":"","keywords":"Multiple myeloma; Clinical endpoint; Daratumumab; Subgroup analysis; Post-hoc analysis; Population; Overall survival; Phases of clinical research; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00224093,0.0005808959,0.002244808,0.000431891,0.0002652257,0.0008306052,0.0004330063,0.000582537,0.001187863],"category_scores_gemma":[0.001688754,0.0003453528,0.003769564,0.0005623761,0.0002962219,0.0005143202,0.0005488422,0.00105577,0.0001692325],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004690632,"about_ca_system_score_gemma":0.0007520008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00066325,"about_ca_topic_score_gemma":0.002971242,"domain_scores_codex":[0.9992355,0.0003549658,0.0001005136,0.0001299087,0.00007168965,0.0001073295],"domain_scores_gemma":[0.9991251,0.0002783145,0.0002310684,0.0001155339,0.00003921808,0.0002108521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.732633,0.003006384,0.1983196,0.0007818358,0.01645064,0.0004779768,0.0002896815,0.001633897,0.007280586,0.0001628679,0.001431883,0.03753168],"study_design_scores_gemma":[0.1699273,0.1736988,0.6081265,0.0002242438,0.03041736,0.001475451,0.000628172,0.005523453,0.002715059,0.0009927382,0.006131708,0.0001391778],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9975938,0.001494516,0.0001004978,0.00007739553,0.00003461949,0.0001384009,0.0003498902,0.000004240421,0.0002066599],"genre_scores_gemma":[0.9981862,0.0004515772,0.0001659398,0.000132582,0.00006047408,0.0001268998,0.0006309747,0.000003665982,0.0002417561],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002244808,"threshold_uncertainty_score":0.01185131,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01286749453895294,"score_gpt":0.2869479553716445,"score_spread":0.2740804608326916,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}