{"id":"W4415668968","doi":"10.1016/j.htct.2025.104823","title":"DARATUMUMAB + BORTEZOMIB, LENALIDOMIDE, AND DEXAMETHASONE (DVRD) VS VRD IN TRANSPLANT-INELIGIBLE (TIE)/TRANSPLANT-DEFERRED (TD) NEWLY DIAGNOSED MULTIPLE MYELOMA (NDMM): PHASE 3 CEPHEUS TRIAL CYTOGENETIC SUBGROUP ANALYSIS","year":2025,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Alberta; University of Calgary","funders":"","keywords":"Daratumumab; Post-hoc analysis; Subgroup analysis; Overall survival; Multiple myeloma; Dexamethasone; Randomized controlled trial; Post hoc","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003452523,0.0006072124,0.001810134,0.0008270757,0.0002440396,0.00005430282,0.0001471892,0.0004269937,0.0002159739],"category_scores_gemma":[0.00001578069,0.000491901,0.0004225897,0.0009802388,0.000223119,0.00008745978,0.00001467545,0.0002896232,0.000005257162],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006383273,"about_ca_system_score_gemma":0.0001555531,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009215976,"about_ca_topic_score_gemma":0.0019096,"domain_scores_codex":[0.9967656,0.0003176568,0.0009618512,0.001022368,0.0002828604,0.0006496627],"domain_scores_gemma":[0.9982514,0.0007508207,0.0001238969,0.0004962556,0.00006080353,0.000316799],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2620743,0.01073218,0.6387741,0.0005539484,0.002804475,0.00252031,0.004365412,0.00002018813,0.03467474,0.0003256704,0.0003202207,0.04283445],"study_design_scores_gemma":[0.72162,0.003953915,0.1054268,0.0005042526,0.003911084,0.0003948802,0.0005427973,0.001527084,0.1568178,0.000200821,0.004186205,0.0009144279],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9757963,0.0187318,0.001404188,0.001131035,0.0002220211,0.001976163,0.0001019971,0.00009719579,0.0005392407],"genre_scores_gemma":[0.9275165,0.07037503,0.0003393667,0.0009654732,0.0000360126,0.0003569045,0.0002432208,0.00003760687,0.0001299186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5333473,"threshold_uncertainty_score":0.9997532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0166324887418257,"score_gpt":0.286898841519776,"score_spread":0.2702663527779502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}