{"id":"W4415668968","doi":"10.1016/j.htct.2025.104823","title":"DARATUMUMAB + BORTEZOMIB, LENALIDOMIDE, AND DEXAMETHASONE (DVRD) VS VRD IN TRANSPLANT-INELIGIBLE (TIE)/TRANSPLANT-DEFERRED (TD) NEWLY DIAGNOSED MULTIPLE MYELOMA (NDMM): PHASE 3 CEPHEUS TRIAL CYTOGENETIC SUBGROUP ANALYSIS","year":2025,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research; University of Alberta; University of Calgary","funders":"","keywords":"Daratumumab; Post-hoc analysis; Subgroup analysis; Overall survival; Multiple myeloma; Dexamethasone; Randomized controlled trial; Post hoc","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001335461,0.0006422416,0.002034963,0.0003781506,0.0001888597,0.0008434525,0.0004782528,0.0005262704,0.001778682],"category_scores_gemma":[0.0008617985,0.0002326587,0.001998185,0.0003816324,0.0002776167,0.0004490416,0.0002707805,0.001218405,0.0001935452],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005742914,"about_ca_system_score_gemma":0.0006865763,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008357812,"about_ca_topic_score_gemma":0.003974915,"domain_scores_codex":[0.9996749,0.0001556227,0.0000318163,0.00004827067,0.00002416142,0.00006513686],"domain_scores_gemma":[0.9995288,0.0001500573,0.0001183934,0.00003814822,0.00001988589,0.0001446793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9392273,0.002684418,0.007542214,0.0004805274,0.004348081,0.00008021983,0.00008112148,0.001580666,0.005743582,0.0001466197,0.001069287,0.03701606],"study_design_scores_gemma":[0.6444935,0.2912782,0.04108044,0.0001548984,0.01177588,0.0003610644,0.0001912587,0.003443036,0.003165333,0.0009738666,0.00302074,0.00006180501],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960958,0.002225897,0.0001228856,0.000176319,0.00006412909,0.0002663231,0.0004695668,0.00001868682,0.0005604348],"genre_scores_gemma":[0.9969243,0.001009229,0.0002949608,0.000254607,0.00008757802,0.0002672868,0.0004889077,0.00000598583,0.0006671126],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002034963,"threshold_uncertainty_score":0.007062674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0166324887418257,"score_gpt":0.286898841519776,"score_spread":0.2702663527779502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}