{"id":"W4415669274","doi":"10.1016/j.htct.2025.104548","title":"GERMLINE PREDISPOSITION TO MYELOID MALIGNANCIES: A COMPREHENSIVE ANALYSIS OF CEBPA, DDX41 AND RUNX1","year":2025,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"CEBPA; RUNX1; Germline; Myeloid; Myeloid leukemia; Germline mutation; ETV6; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404815,0.0001679256,0.000735186,0.0006789009,0.00009306108,0.000008147764,0.00006803178,0.0001787868,0.0001902005],"category_scores_gemma":[0.000008602256,0.0001369817,0.0001192572,0.0009407364,0.0001832042,0.00002940455,0.00002959809,0.0001739065,0.000002685601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002732209,"about_ca_system_score_gemma":0.00008690427,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008545671,"about_ca_topic_score_gemma":0.00003445929,"domain_scores_codex":[0.9988227,0.0000924227,0.0003325064,0.0003658006,0.0001526286,0.0002338648],"domain_scores_gemma":[0.9992217,0.0001678091,0.0000437528,0.0002552673,0.0001691706,0.000142229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003313568,0.0003963383,0.0461902,0.0004969849,0.001176136,0.00006357514,0.00274534,0.00001503529,0.93327,0.001738082,0.0007687486,0.009825977],"study_design_scores_gemma":[0.0150399,0.001929526,0.3858634,0.0004116593,0.002002916,0.0002289366,0.002673807,0.003928016,0.57286,0.0003273147,0.01426758,0.0004669264],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9879737,0.004091002,0.003249021,0.003031346,0.00003938765,0.0006524704,0.0000193787,0.00003293602,0.0009106832],"genre_scores_gemma":[0.982832,0.0131568,0.000777225,0.002344897,0.00001115971,0.00004619284,0.00004110149,0.00001272126,0.0007779631],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.36041,"threshold_uncertainty_score":0.5585953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0140609083902808,"score_gpt":0.2959140025763212,"score_spread":0.2818530941860404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}