{"id":"W4415669274","doi":"10.1016/j.htct.2025.104548","title":"GERMLINE PREDISPOSITION TO MYELOID MALIGNANCIES: A COMPREHENSIVE ANALYSIS OF CEBPA, DDX41 AND RUNX1","year":2025,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"","keywords":"CEBPA; RUNX1; Germline; Myeloid; Myeloid leukemia; Germline mutation; ETV6; Mutation; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004096155,0.0002520043,0.0003475238,0.001607522,0.0003235608,0.0004103273,0.0002420994,0.0002579275,0.001929375],"category_scores_gemma":[0.0008356144,0.0001521691,0.0004921246,0.001471803,0.0002031852,0.0001401645,0.000520682,0.0002504135,0.0004374482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002155993,"about_ca_system_score_gemma":0.0002923688,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001857091,"about_ca_topic_score_gemma":0.003003054,"domain_scores_codex":[0.9996057,0.00003265268,0.00003502867,0.000157725,0.0001232986,0.00004553163],"domain_scores_gemma":[0.9995984,0.00009709907,0.0001351685,0.00004220851,0.00005496451,0.00007218027],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.000465253,0.00002521005,0.8968718,0.0001730799,0.0003379587,0.001784752,0.0003152705,0.0007684878,0.06583881,0.0002097851,0.001188686,0.03202085],"study_design_scores_gemma":[0.00001406435,0.00007434006,0.982437,0.00003801379,0.0002359404,0.005295741,0.0001149,0.0009302913,0.005138275,0.0001849011,0.0055245,0.00001208376],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931491,0.001536177,0.0008740666,0.00006326712,0.000004767232,0.00002348397,0.003542605,0.00004878895,0.000757782],"genre_scores_gemma":[0.9917083,0.0008318879,0.001694953,0.00006338101,0.00001164962,0.00002383129,0.005152085,0.00004686566,0.0004669455],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001929375,"threshold_uncertainty_score":0.006454408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0140609083902808,"score_gpt":0.2959140025763212,"score_spread":0.2818530941860404,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}