{"id":"W4415671955","doi":"10.1073/pnas.2419568122","title":"Metabolic adaptation of glucose-deprived macrophages involves partial gluconeogenesis","year":2025,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Immune cells in cancer","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"IONICS Mass Spectrometry (Canada)","funders":"HORIZON EUROPE European Innovation Council; Bundesministerium für Bildung, Wissenschaft und Forschung; European Innovation Council and Small and Medium-sized Enterprises Executive Agency; Medizinische Universität Graz; European Research Council; Vlaams Instituut voor Biotechnologie; KU Leuven; Austrian Science Fund; European Commission; Karl-Franzens-Universität Graz; European Molecular Biology Organization","keywords":"Gluconeogenesis; Glycolysis; Phosphoenolpyruvate carboxykinase; Glutaminolysis; Citric acid cycle; Glutamine; Macrophage; Immune system; Metabolic pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007670128,0.0002801052,0.0001685053,0.0000884914,0.00007864738,0.0002259304,0.0001091251,0.0001540868,0.0004358885],"category_scores_gemma":[0.0000467987,0.00007740276,0.0001424441,0.00008288496,0.0001933042,0.0001205315,0.0001970655,0.000269792,0.000135061],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001524678,"about_ca_system_score_gemma":0.0001293615,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002526885,"about_ca_topic_score_gemma":0.0004237708,"domain_scores_codex":[0.9999212,0.00001518044,0.000005272448,0.00001872524,0.00001750209,0.00002208364],"domain_scores_gemma":[0.9999661,0.000003842993,0.000006949478,0.000007505697,0.000005343753,0.00001026518],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008085711,0.00000391441,0.0002017442,0.00001111612,0.000002045614,0.00002421629,0.000003050017,0.00001463758,0.9991876,0.00002914145,0.000006464483,0.0004351056],"study_design_scores_gemma":[0.000007552272,0.0001250338,0.008963821,0.00000466822,0.000008762619,0.00022258,0.00002663432,0.0003077413,0.9890399,0.00006148688,0.001228416,0.000003479723],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944718,0.001569182,0.002818262,0.00006204429,0.00001745488,0.00001262715,0.0002520085,0.00003131748,0.000765432],"genre_scores_gemma":[0.9967032,0.0006374368,0.001307036,0.0000506529,0.000003749838,0.00002172199,0.0003381952,0.00001143407,0.000926498],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004358885,"threshold_uncertainty_score":0.001458168,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03293026824943269,"score_gpt":0.2936820549413757,"score_spread":0.260751786691943,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}