{"id":"W4415672736","doi":"10.1002/em.70040","title":"The In Vitro Transgenic Rodent Assay in Primary <scp>MutaMouse</scp> Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the <scp>HPRT</scp> Gene","year":2025,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Canada","keywords":"In vitro; In vivo; In vitro toxicology; Mutant; Gene; Mutation; Transgene; Gene mutation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009154493,0.0009182841,0.0004622682,0.0006649566,0.0001905085,0.000331736,0.0003603141,0.0004547442,0.001531818],"category_scores_gemma":[0.0006907745,0.0002985365,0.0005191141,0.0003875639,0.0003363047,0.0002377302,0.0003107755,0.0007434397,0.0005967896],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002630612,"about_ca_system_score_gemma":0.0003616035,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001151647,"about_ca_topic_score_gemma":0.003116644,"domain_scores_codex":[0.9983178,0.0005783037,0.0001515428,0.0003808156,0.0004957961,0.00007578261],"domain_scores_gemma":[0.9988497,0.0003597973,0.000311814,0.0001842874,0.0002353646,0.00005890139],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006280049,0.00003999853,0.000800407,0.00005274551,0.00001599363,0.00004191901,0.00001806856,0.00008529015,0.9975188,0.00003951096,0.00002495981,0.001299609],"study_design_scores_gemma":[0.000003182894,0.0007619523,0.003339112,0.000003568696,0.00003553859,0.0001927156,0.000011522,0.0004180094,0.9946868,0.00001697089,0.000525206,0.000005288303],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9012548,0.002453437,0.08990369,0.0001121086,0.0001163536,0.0003056337,0.001233555,0.0005882711,0.004032196],"genre_scores_gemma":[0.9175237,0.00333472,0.06750523,0.0002031335,0.00003786839,0.0004206299,0.002105757,0.000130922,0.008738075],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001531818,"threshold_uncertainty_score":0.00512439,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005921815917533602,"score_gpt":0.2136935923308991,"score_spread":0.2077717764133655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}