{"id":"W4415672736","doi":"10.1002/em.70040","title":"The In Vitro Transgenic Rodent Assay in Primary <scp>MutaMouse</scp> Hepatocytes Compared to the Mammalian Cell Gene Mutation Assay Using the <scp>HPRT</scp> Gene","year":2025,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health Canada","keywords":"In vitro; In vivo; In vitro toxicology; Mutant; Gene; Mutation; Transgene; Gene mutation","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000801607,0.0003662853,0.0002751499,0.00009269833,0.0003978646,0.0001156837,0.000439566,0.0001689772,0.000002884785],"category_scores_gemma":[0.0000321747,0.0002573381,0.0001965647,0.0002108263,0.0001731025,0.000009715767,0.0003518912,0.0001937389,0.000007756227],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001959269,"about_ca_system_score_gemma":0.00008102488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001890205,"about_ca_topic_score_gemma":0.0002660347,"domain_scores_codex":[0.997489,0.0005179573,0.0004438067,0.0006529161,0.000347491,0.0005487662],"domain_scores_gemma":[0.9990273,0.0001364812,0.0001127123,0.0006025019,0.00001198183,0.0001090753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002436179,0.0001533387,0.005044231,0.00001893819,0.00007679767,0.00003940715,0.0004041179,0.005063598,0.9873205,0.000003848564,0.000113084,0.001737709],"study_design_scores_gemma":[0.0007937465,0.00006923232,0.05937742,0.000009045937,0.00009072115,0.00002344918,0.001281415,0.001076058,0.9288357,0.00001784508,0.008336483,0.00008889633],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843756,0.006673999,0.007176663,0.000290665,0.0001281485,0.001077447,0.00009923723,0.000008701378,0.0001695638],"genre_scores_gemma":[0.9961575,0.000714701,0.0006683107,0.001300078,0.00005889653,0.0001949907,0.0002339427,0.0000434409,0.0006281844],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05848489,"threshold_uncertainty_score":0.9999879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005921815917533602,"score_gpt":0.2136935923308991,"score_spread":0.2077717764133655,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}