{"id":"W4415672811","doi":"10.1111/andr.70131","title":"Advanced Paternal Age Impacts Common Loci in the Sperm and Placenta DNA Methylomes","year":2025,"lang":"en","type":"article","venue":"Andrology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université de Montréal; Université de Sherbrooke; Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal; University of Toronto; Douglas College; McGill University; Centre Hospitalier Universitaire de Sherbrooke; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; University of Toronto; Canadian Institutes of Health Research; McGill University Health Centre; Université de Sherbrooke; McGill University; University of Ottawa; Université de Montréal; Université Laval","keywords":"DNA methylation; Sperm; Paternal age; Methylation; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002762161,0.0002046241,0.0002450992,0.0005348333,0.0001812046,0.0003591472,0.0001377372,0.0002516362,0.002375905],"category_scores_gemma":[0.000911204,0.0001665256,0.0002761479,0.0004503712,0.0001885861,0.0001477338,0.0002947466,0.0001939515,0.0001653129],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002129755,"about_ca_system_score_gemma":0.0002218454,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002291168,"about_ca_topic_score_gemma":0.002785206,"domain_scores_codex":[0.9997483,0.00005656711,0.00001606406,0.00008898806,0.00005140484,0.00003868177],"domain_scores_gemma":[0.9994383,0.0001547789,0.000243402,0.0000401205,0.00005316801,0.00007019523],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001396899,0.00003414925,0.7946076,0.0001704771,0.0003744786,0.0005315898,0.0004278118,0.0003355161,0.185825,0.0002688603,0.0002281323,0.01579958],"study_design_scores_gemma":[0.00000634566,0.0001443145,0.9912151,0.00001158885,0.00009083781,0.0006844152,0.0000758945,0.0002458756,0.00687132,0.0001404021,0.0005083419,0.00000564117],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959253,0.001639289,0.001014996,0.00004768163,0.000008235163,0.000004212805,0.0008701816,0.0000147833,0.0004753468],"genre_scores_gemma":[0.9982377,0.0005423502,0.0004817727,0.0000221048,0.000005151177,0.000003581114,0.0003535318,0.000007708836,0.0003461649],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002375905,"threshold_uncertainty_score":0.00794816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007061889577092552,"score_gpt":0.2842582279949476,"score_spread":0.2771963384178551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}