{"id":"W4415672811","doi":"10.1111/andr.70131","title":"Advanced Paternal Age Impacts Common Loci in the Sperm and Placenta DNA Methylomes","year":2025,"lang":"en","type":"article","venue":"Andrology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Université de Montréal; Université de Sherbrooke; Centre Hospitalier Universitaire Sainte-Justine; Université du Québec à Montréal; University of Toronto; Douglas College; McGill University; Centre Hospitalier Universitaire de Sherbrooke; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; University of Toronto; Canadian Institutes of Health Research; McGill University Health Centre; Université de Sherbrooke; McGill University; University of Ottawa; Université de Montréal; Université Laval","keywords":"DNA methylation; Sperm; Paternal age; Methylation; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002215535,0.00008530105,0.0001147998,0.00004236832,0.00004390088,0.00001518208,0.000110461,0.0001150749,0.000005807279],"category_scores_gemma":[0.0000342275,0.00006349165,0.00002686011,0.00006197998,0.00006758887,0.000002072089,0.00006439248,0.00008081899,0.000001279647],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005051018,"about_ca_system_score_gemma":0.00001752505,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006022481,"about_ca_topic_score_gemma":0.000673068,"domain_scores_codex":[0.9993681,0.0001184195,0.0001301052,0.0001783761,0.00004167607,0.0001632889],"domain_scores_gemma":[0.999719,0.00003463516,0.00003393921,0.0001772456,0.00001228339,0.00002292583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0002099464,0.00006957355,0.2012916,0.00002193081,0.00003919624,0.00002619802,0.0002510633,0.00005650138,0.7816195,0.0006114805,0.0003011805,0.01550178],"study_design_scores_gemma":[0.002288485,0.0008182026,0.5602149,0.00001653741,0.00003469839,0.00001556341,0.0001787914,0.00008169984,0.3742142,0.00776086,0.05414688,0.0002291371],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937048,0.003601399,0.0001226451,0.0006465629,0.00008439351,0.0001167684,0.000004395513,0.000002894337,0.001716127],"genre_scores_gemma":[0.9975051,0.001218647,0.00008028311,0.0008943939,0.00003934886,0.00000903192,0.00005642145,0.000004833344,0.0001919573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4074054,"threshold_uncertainty_score":0.2589114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007061889577092552,"score_gpt":0.2842582279949476,"score_spread":0.2771963384178551,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}