{"id":"W4415673834","doi":"10.1002/cph4.70066","title":"Disrupting <scp>BMP</scp> / <scp>TGF</scp> ‐β Signaling: Modulation of <i>AQP1</i> and <i>TGFB1</i> in Human Pulmonary Microvascular Endothelial Cells","year":2025,"lang":"en","type":"article","venue":"Comprehensive physiology","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Stavros Niarchos Foundation; Hellenic Academic Libraries Link","keywords":"Gene silencing; BMPR2; Messenger RNA; Gene; Signal transduction; Aquaporin 1; Gene expression; TRPC3; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001419887,0.0003063403,0.0002320552,0.0001404642,0.0001410919,0.0002213195,0.0001206404,0.0002568989,0.00101248],"category_scores_gemma":[0.00008758523,0.0001085577,0.0002892301,0.000153706,0.0002561146,0.0001716989,0.0001159961,0.0007195793,0.0002444385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001640537,"about_ca_system_score_gemma":0.0002305847,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008008299,"about_ca_topic_score_gemma":0.0009945674,"domain_scores_codex":[0.9998621,0.00002105199,0.00001524729,0.00002736908,0.00004369585,0.00003046366],"domain_scores_gemma":[0.9999331,0.00001434174,0.00002006198,0.000006656261,0.00001029607,0.00001562103],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004514335,0.00001551378,0.00006610504,0.00003673115,0.000003025703,0.00001874699,0.000009447638,0.00002893253,0.99927,0.00002941857,0.0000160144,0.0004608743],"study_design_scores_gemma":[0.00001069409,0.0001710911,0.001956907,0.000005270479,0.00001414587,0.0001082886,0.00002722729,0.0004569283,0.9955902,0.00002340748,0.001633112,0.000002796654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882796,0.003486108,0.005007434,0.0003124184,0.00007683123,0.00006669658,0.0006521363,0.00008043947,0.002038348],"genre_scores_gemma":[0.9893563,0.002731211,0.003944661,0.0002051184,0.0000186574,0.0001063043,0.0007010867,0.00003008642,0.002906549],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00101248,"threshold_uncertainty_score":0.003387094,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02100137053480871,"score_gpt":0.2881442539346006,"score_spread":0.2671428833997919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}