{"id":"W4415673834","doi":"10.1002/cph4.70066","title":"Disrupting <scp>BMP</scp> / <scp>TGF</scp> ‐β Signaling: Modulation of <i>AQP1</i> and <i>TGFB1</i> in Human Pulmonary Microvascular Endothelial Cells","year":2025,"lang":"en","type":"article","venue":"Comprehensive physiology","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"Stavros Niarchos Foundation; Hellenic Academic Libraries Link","keywords":"Gene silencing; BMPR2; Messenger RNA; Gene; Signal transduction; Aquaporin 1; Gene expression; TRPC3; Lung","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001325225,0.0003725493,0.000977156,0.0004225443,0.0001723765,0.00001425669,0.0001873524,0.0002279916,0.00000730472],"category_scores_gemma":[0.000237426,0.0003371225,0.0002319352,0.0004404275,0.0003766237,0.0001026421,0.0003060786,0.0004140859,0.00001744657],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006471932,"about_ca_system_score_gemma":0.0001102794,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001787885,"about_ca_topic_score_gemma":0.000004666676,"domain_scores_codex":[0.997453,0.0003026753,0.0005842688,0.0007378155,0.0002778752,0.0006443813],"domain_scores_gemma":[0.9975724,0.001142979,0.0001885763,0.0005213351,0.0003799463,0.000194731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000632092,0.0006437543,0.01093563,0.0003698104,0.000265785,0.0004134412,0.0001614319,0.0002314209,0.9854168,0.00009997622,0.0006991688,0.0006995167],"study_design_scores_gemma":[0.006502532,0.0008480331,0.3366939,0.0005636066,0.0002551971,0.0001718526,0.0014072,0.004165418,0.6353831,0.00335319,0.01052857,0.0001274826],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9946447,0.003013765,0.00005740139,0.00008105192,0.0001697251,0.0008127987,0.00004573112,0.00005046101,0.001124359],"genre_scores_gemma":[0.9971749,0.0004497257,0.0003467731,0.0007696547,0.0001106398,0.00005094804,0.0002245708,0.00003696416,0.0008358137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3500338,"threshold_uncertainty_score":0.9999081,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02100137053480871,"score_gpt":0.2881442539346006,"score_spread":0.2671428833997919,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}