{"id":"W4415677491","doi":"10.1016/j.vaccine.2025.127914","title":"Enhanced immunogenicity of swine coronavirus PEDV by engineering transcriptional regulatory sequences","year":2025,"lang":"en","type":"article","venue":"Vaccine","topic":"Animal Virus Infections Studies","field":"Agricultural and Biological Sciences","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ministry of Agriculture","funders":"National Key Research and Development Program of China; Natural Science Foundation of Jiangsu Province; National Natural Science Foundation of China; Science and Technology Plan Project of Taizhou; Jiangsu Agricultural Science and Technology Innovation Fund","keywords":"Porcine epidemic diarrhea virus; Immunogenicity; Coronavirus; Antibody; Gene; Recombinant DNA; Gene expression; Vero cell; Transcription (linguistics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003811326,0.0002872317,0.0001610747,0.0001886916,0.0001228237,0.000285847,0.0001758589,0.0002297081,0.0008349633],"category_scores_gemma":[0.0002113819,0.0001200808,0.0002884057,0.00009202889,0.000226519,0.0001514056,0.000216011,0.0007018894,0.0002054621],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003172165,"about_ca_system_score_gemma":0.0002220432,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003510954,"about_ca_topic_score_gemma":0.0005657665,"domain_scores_codex":[0.9998492,0.0000456493,0.00001200487,0.0000223561,0.00002646324,0.00004429595],"domain_scores_gemma":[0.9998813,0.00004129091,0.00002782916,0.0000129389,0.00001669193,0.00002002667],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000144805,0.00008962921,0.0001752231,0.00002426914,0.0000043342,0.00003751,0.00001668924,0.0002768518,0.9974853,0.0002599529,0.00001894105,0.001466587],"study_design_scores_gemma":[0.0000359778,0.000447193,0.0009932325,0.000008172905,0.00002213414,0.00008827478,0.00003001388,0.002156675,0.9944928,0.00005449765,0.001666779,0.000004298087],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935318,0.0002557348,0.005382337,0.0000545118,0.00003338856,0.00003135351,0.00007964588,0.00002802569,0.0006031361],"genre_scores_gemma":[0.9952447,0.0001517454,0.003220291,0.0000376004,0.000008021329,0.0000136244,0.0002557536,0.00001540573,0.001052777],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008349633,"threshold_uncertainty_score":0.002793252,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01404994930165171,"score_gpt":0.2298895829319726,"score_spread":0.2158396336303209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}