{"id":"W4415678781","doi":"10.1016/s1470-2045(25)00472-3","title":"Vorasidenib in IDH1-mutant or IDH2-mutant low-grade glioma (INDIGO): secondary and exploratory endpoints from a randomised, double-blind, placebo-controlled, phase 3 trial","year":2025,"lang":"en","type":"article","venue":"The Lancet Oncology","topic":"Glioma Diagnosis and Treatment","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre; Princess Margaret Cancer Centre; Health Sciences Centre; University Health Network","funders":"Servier","keywords":"Phase (matter); Glioma; Clinical trial; Phases of clinical research; Glioblastoma","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001303126,0.001445322,0.002395571,0.0003642673,0.0002985476,0.001044125,0.0006316669,0.001381016,0.004775483],"category_scores_gemma":[0.0012377,0.0004006054,0.00201212,0.0003768512,0.0008929436,0.0009245111,0.0003219321,0.00332797,0.0007682695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008349388,"about_ca_system_score_gemma":0.0008473703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008279684,"about_ca_topic_score_gemma":0.002918031,"domain_scores_codex":[0.9996638,0.000172127,0.00001606969,0.00005156488,0.00002588773,0.00007048755],"domain_scores_gemma":[0.999491,0.0001686892,0.0001001464,0.00003404224,0.0000350363,0.0001710032],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9657623,0.002493218,0.0005157639,0.001637153,0.001785492,0.00005873821,0.0000714124,0.0005110438,0.004724878,0.0002556591,0.002035785,0.02014857],"study_design_scores_gemma":[0.9337806,0.06045431,0.001917828,0.00008308289,0.0009229002,0.00007818601,0.00004417694,0.0003702879,0.00075043,0.0003265861,0.001249927,0.00002173787],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9766195,0.01438988,0.0005974306,0.00111917,0.0006798971,0.001509509,0.001648616,0.0001680224,0.003268015],"genre_scores_gemma":[0.9846757,0.006013019,0.0009132212,0.001213548,0.0003244659,0.001686721,0.001834062,0.00003251751,0.00330671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004775483,"threshold_uncertainty_score":0.01597559,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05830452800028042,"score_gpt":0.3686986930068263,"score_spread":0.3103941650065459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}