{"id":"W4415678807","doi":"10.1016/j.ebiom.2025.105980","title":"Safety and efficacy of intratumourally administered INT230-6 in adult patients with advanced solid tumours: results from an open-label phase 1/2 dose escalation study","year":2025,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Clinical trial; Phases of clinical research; De-escalation; Maximum tolerated dose; Phase (matter); Intensity (physics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001744979,0.0002294651,0.000720745,0.0002117929,0.00007187618,0.00001610517,0.0001215367,0.00004776516,0.00001132811],"category_scores_gemma":[0.0002867059,0.0001537606,0.00001210444,0.0005215706,0.0001492944,0.0001574439,0.0001239267,0.000142969,5.719647e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000126164,"about_ca_system_score_gemma":0.0001258262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006095737,"about_ca_topic_score_gemma":0.001145046,"domain_scores_codex":[0.9983106,0.00006599712,0.0006645491,0.0004844897,0.0002769813,0.000197357],"domain_scores_gemma":[0.9989328,0.0001499399,0.0002057768,0.0003320746,0.0002565345,0.0001228609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2768123,0.0385451,0.3088508,0.0001065012,0.0007878576,0.0001904557,0.01513877,0.000004230748,0.002389295,0.00003599652,0.0002653781,0.3568732],"study_design_scores_gemma":[0.1854172,0.02605232,0.7852832,0.0007788732,0.000263638,9.538927e-7,0.00169381,0.0001105387,0.0002015339,0.00001539367,0.00007037295,0.0001121356],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949597,0.0001816354,0.00001339437,0.001379454,0.0001320657,0.002226206,0.0001682324,0.00002432106,0.000914972],"genre_scores_gemma":[0.9984621,0.00006347683,0.0003920669,0.0002431153,0.00004070532,0.00004477536,0.0006018958,0.00001446096,0.0001374071],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4764324,"threshold_uncertainty_score":0.6270174,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901681330218613,"score_gpt":0.3618939982504237,"score_spread":0.3428771849482376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}