{"id":"W4415678807","doi":"10.1016/j.ebiom.2025.105980","title":"Safety and efficacy of intratumourally administered INT230-6 in adult patients with advanced solid tumours: results from an open-label phase 1/2 dose escalation study","year":2025,"lang":"en","type":"article","venue":"EBioMedicine","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Clinical trial; Phases of clinical research; De-escalation; Maximum tolerated dose; Phase (matter); Intensity (physics)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001545677,0.0006874694,0.001057247,0.0002084575,0.000223641,0.0006024302,0.0004715217,0.0005595712,0.00166865],"category_scores_gemma":[0.0007553311,0.0002728369,0.0006944342,0.0002989717,0.0004848684,0.000591749,0.0002112705,0.001943425,0.0005426679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005096216,"about_ca_system_score_gemma":0.0006783133,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004130398,"about_ca_topic_score_gemma":0.000819214,"domain_scores_codex":[0.9996289,0.0001766616,0.00002474502,0.00005782379,0.00006645513,0.00004529763],"domain_scores_gemma":[0.9993497,0.00009241238,0.0002342484,0.00005327414,0.0000594878,0.0002109852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.3938842,0.06729998,0.03027277,0.001473624,0.002280833,0.0004263705,0.0006917126,0.004608281,0.1851408,0.0002348353,0.006883273,0.3068033],"study_design_scores_gemma":[0.1699968,0.7439324,0.0570287,0.00007927944,0.001095005,0.001152838,0.0001266657,0.002567767,0.01685555,0.0002471395,0.006860776,0.00005713225],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955848,0.00255948,0.0003339582,0.0001478352,0.00002000145,0.0003307806,0.0003781436,0.0000537749,0.0005910943],"genre_scores_gemma":[0.9953921,0.001518445,0.000894216,0.0002893408,0.00004591779,0.0003933847,0.0008344653,0.00002092341,0.0006112227],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00166865,"threshold_uncertainty_score":0.008174419,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01901681330218613,"score_gpt":0.3618939982504237,"score_spread":0.3428771849482376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}