{"id":"W4415679865","doi":"10.1016/j.jpsychires.2025.10.056","title":"The effects of ketamine and esketamine on functional outcomes in major depressive disorder and treatment-resistant depression: A systematic review","year":2025,"lang":"en","type":"review","venue":"Journal of Psychiatric Research","topic":"Treatment of Major Depression","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Brain and Cognition Discovery Foundation; Queen's University","funders":"","keywords":"Major depressive disorder; Ketamine; Depression (economics); Depressive symptoms; Treatment-resistant depression; Meta-analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001958614,0.0005150894,0.00423326,0.001442083,0.0002144502,0.00004832292,0.0002913387,0.0002496928,0.00001048021],"category_scores_gemma":[0.004336901,0.0002210842,0.0006660131,0.001024266,0.0001662488,0.0000631349,0.0001549896,0.0009562433,0.000002849345],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002876774,"about_ca_system_score_gemma":0.0006964494,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002358411,"about_ca_topic_score_gemma":0.0000220269,"domain_scores_codex":[0.9938625,0.001748625,0.002013064,0.0004400043,0.001540048,0.0003957377],"domain_scores_gemma":[0.9863883,0.01090469,0.001377327,0.0007323295,0.0003712573,0.0002261457],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0005099025,0.0008540704,0.004872792,0.8428063,0.001335634,0.0002500991,0.00001584414,7.8598e-8,0.00000148444,0.00003378752,0.0009569576,0.1483631],"study_design_scores_gemma":[0.007831088,0.003086371,0.009271608,0.9581848,0.01055045,0.0004641483,0.00004028565,0.000001525769,0.000002792483,0.00005569521,0.01030802,0.0002031657],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009154891,0.9927163,0.000003799748,0.0006867847,0.0003123488,0.005181624,0.00001350446,0.000005703949,0.0001644921],"genre_scores_gemma":[0.0003792621,0.9964139,0.00009574086,0.00002096561,0.0001133567,0.0004088787,0.000009227457,0.00003921926,0.002519462],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.1481599,"threshold_uncertainty_score":0.9015551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03620898572306241,"score_gpt":0.4014216520112325,"score_spread":0.3652126662881701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}