{"id":"W4415680644","doi":"10.3390/curroncol32110604","title":"New Horizons with Growth Differentiation Factor 15 in Oncology: From Cancer Cachexia and Tumour Immunity to Novel Therapeutic Strategies","year":2025,"lang":"en","type":"article","venue":"Current Oncology","topic":"GDF15 and Related Biomarkers","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Department of Health and Social Care; National Institute for Health and Care Research; Royal Marsden NHS Foundation Trust","keywords":"Cachexia; Cancer; New horizons; Clinical trial; Immune system; Cytokine; Cancer therapy; Cancer cachexia; Therapeutic approach","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001803118,0.0006223616,0.001221037,0.001235719,0.0003251676,0.00177428,0.0006833154,0.001857616,0.003616816],"category_scores_gemma":[0.001344459,0.0002253972,0.0006697825,0.0009476611,0.00130947,0.003808742,0.001265495,0.004453034,0.001094109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009962972,"about_ca_system_score_gemma":0.001311617,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005480716,"about_ca_topic_score_gemma":0.002180278,"domain_scores_codex":[0.9996397,0.0001371073,0.00003392446,0.00004105487,0.00009469507,0.00005334574],"domain_scores_gemma":[0.9991845,0.000439906,0.00007361385,0.00002785364,0.0001457746,0.000128221],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005327304,0.0002698358,0.0009106222,0.008386466,0.0001724181,0.0006818157,0.0003566983,0.0009269852,0.007902529,0.03204935,0.06158887,0.8862217],"study_design_scores_gemma":[0.0001394089,0.0008551624,0.001315033,0.003464538,0.0001375362,0.001363428,0.0004032171,0.000507599,0.001630659,0.02644916,0.963675,0.00005926829],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.0007912844,0.9866246,0.0007015193,0.00935977,0.001082968,0.00001136388,0.00002132691,0.00001846044,0.001388688],"genre_scores_gemma":[0.006735384,0.98234,0.001614199,0.004652943,0.00314498,0.00003285738,0.00005756782,0.00000968071,0.001412348],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.003616816,"threshold_uncertainty_score":0.01209944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06179751769984406,"score_gpt":0.3871944737165716,"score_spread":0.3253969560167276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}