{"id":"W4415683763","doi":"10.3390/bios15110716","title":"A Screening Assay for Bile Acid-Transforming Microorganisms Using Engineered Bacterial Biosensors","year":2025,"lang":"en","type":"article","venue":"Biosensors","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Fondazione Cassa di Risparmio di Padova e Rovigo; Université de Montpellier; Dankook University; Università degli Studi di Pavia; Ministero dell'Università e della Ricerca; Concordia University","keywords":"Biosensor; Probiotic; Microorganism; Recombinant DNA; Bacteria; Enzyme; High-throughput screening; Bile acid","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008230492,0.001223787,0.0007674522,0.0006701557,0.0002024336,0.0005822639,0.0007767784,0.001190265,0.0004607816],"category_scores_gemma":[0.001010902,0.0003609954,0.0005176801,0.0006286159,0.0003106422,0.0004129698,0.0007126484,0.0006921814,0.0005176999],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002700429,"about_ca_system_score_gemma":0.0002829843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000340203,"about_ca_topic_score_gemma":0.0004085308,"domain_scores_codex":[0.9979831,0.0005295738,0.0001761124,0.0004086898,0.0007640087,0.0001385475],"domain_scores_gemma":[0.9994617,0.0001758411,0.0001052211,0.00006624825,0.0001353386,0.00005570857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001775406,0.00002958227,0.0001086215,0.00003846275,0.000005171276,0.00001333428,0.00001092197,0.00004298702,0.9983638,0.00002858772,0.00001080386,0.001330027],"study_design_scores_gemma":[0.000002707059,0.0002021219,0.0004284961,0.000005799161,0.00001170358,0.00008561508,0.0000136897,0.0008541866,0.9979472,0.00001751858,0.0004247526,0.000006353408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.741624,0.003539989,0.2495583,0.000378495,0.0001822121,0.0004003322,0.0008243099,0.001116001,0.002376348],"genre_scores_gemma":[0.7566814,0.002848732,0.2338559,0.0001383688,0.00004233867,0.0004804938,0.001442926,0.00007407703,0.004435866],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001223787,"threshold_uncertainty_score":0.004352748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01328786248610686,"score_gpt":0.2576614730743809,"score_spread":0.244373610588274,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}