{"id":"W4415685608","doi":"10.1002/dev.70097","title":"Cross‐Tissue Specificity of Pediatric DNA Methylation Associated With Cumulative Family Stress","year":2025,"lang":"en","type":"article","venue":"Developmental Psychobiology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Advancing Health Outcomes; BC Children's Hospital; University of British Columbia","funders":"National Institutes of Health; W. Garfield Weston Foundation","keywords":"dNaM; DNA methylation; Buccal swab; Peripheral blood mononuclear cell; Haplotype; Stressor; Methylation; Cumulative risk","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002413219,0.0001747489,0.0002103502,0.0001198994,0.00008115365,0.00001189615,0.0001522603,0.0002471872,0.0000338063],"category_scores_gemma":[0.00009502022,0.0001583,0.00004177919,0.0003080433,0.0001225474,0.000004949148,0.00006796473,0.00008362168,0.000004685586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003902966,"about_ca_system_score_gemma":0.0001225747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002164308,"about_ca_topic_score_gemma":0.00007694665,"domain_scores_codex":[0.998816,0.0001152383,0.0003685642,0.0003919711,0.00009537734,0.00021281],"domain_scores_gemma":[0.9993572,0.00005151281,0.0002010527,0.0001650493,0.0001871105,0.00003806295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001853723,0.000141969,0.3541211,0.000015432,0.0001475831,9.280366e-7,0.00008008673,0.0001602539,0.6418672,0.0001267891,0.0002079866,0.002945418],"study_design_scores_gemma":[0.0006571721,0.0001872051,0.5551181,0.00001071773,0.00001805702,3.149684e-7,0.00005281291,0.000007135941,0.4415768,0.0002154006,0.002008909,0.0001473526],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987076,0.0007881534,0.004499,0.00002175479,0.0002767017,0.0002447233,0.00007386452,0.00001236805,0.007007469],"genre_scores_gemma":[0.9965531,0.0001934994,0.001430481,0.00006052749,0.00006884615,0.00001633908,0.0007147794,0.00001329651,0.000949119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2009971,"threshold_uncertainty_score":0.6455286,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01928939001705185,"score_gpt":0.3107516426270785,"score_spread":0.2914622526100267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}