{"id":"W4415685608","doi":"10.1002/dev.70097","title":"Cross‐Tissue Specificity of Pediatric DNA Methylation Associated With Cumulative Family Stress","year":2025,"lang":"en","type":"article","venue":"Developmental Psychobiology","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Advancing Health Outcomes; BC Children's Hospital; University of British Columbia","funders":"National Institutes of Health; W. Garfield Weston Foundation","keywords":"dNaM; DNA methylation; Buccal swab; Peripheral blood mononuclear cell; Haplotype; Stressor; Methylation; Cumulative risk","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001966012,0.0001608429,0.0002063628,0.0004236656,0.0002847823,0.00030723,0.0001599587,0.0001561501,0.00150243],"category_scores_gemma":[0.0006951593,0.0001028482,0.0001317185,0.0004570392,0.0002210298,0.00009436718,0.0003583458,0.0002142915,0.00008864815],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004445056,"about_ca_system_score_gemma":0.000447719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.04980421,"about_ca_topic_score_gemma":0.1114278,"domain_scores_codex":[0.9997553,0.00003275707,0.00001036345,0.0001105484,0.0000388666,0.00005213858],"domain_scores_gemma":[0.9997211,0.00005576663,0.0000976215,0.00002418021,0.0000634398,0.00003786336],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001244176,0.000007850743,0.9682499,0.00003464544,0.00006766798,0.0001501304,0.0005895356,0.0001123156,0.02386517,0.0001064973,0.00009025268,0.006601667],"study_design_scores_gemma":[5.665585e-7,0.00001297422,0.9975526,0.00000405528,0.00001424001,0.0001384225,0.0001928375,0.00007748937,0.001754447,0.00003570606,0.0002152745,0.000001438645],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979407,0.0004522606,0.0004442667,0.00003259437,0.000002671679,0.000003402289,0.0006035143,0.00000717848,0.0005133082],"genre_scores_gemma":[0.9992164,0.0001336004,0.0001942853,0.0000115877,0.00000135385,0.000003753733,0.0001925757,0.000002314589,0.0002441108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04980421,"threshold_uncertainty_score":0.09902865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01928939001705185,"score_gpt":0.3107516426270785,"score_spread":0.2914622526100267,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}