{"id":"W4415688853","doi":"10.32604/or.2025.069408","title":"CXCR1 and CXCR2 Antagonism with G31P Attenuates Chemotherapy-Induced Lung Inflammation and Augments the Gefitinib Therapeutic Response in Lung Cancer","year":2025,"lang":"en","type":"article","venue":"Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics","topic":"Chemokine receptors and signaling","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal University Hospital","funders":"","keywords":"Gefitinib; Antagonism; Lung cancer; Epidermal growth factor receptor; Inflammation; Tyrosine kinase; Adjuvant; Tyrosine-kinase inhibitor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.005629255,0.0002926078,0.000806792,0.0001767782,0.0003722532,0.00009938255,0.0001994507,0.0005658157,0.00004282579],"category_scores_gemma":[0.0003642055,0.0001819279,0.00008836891,0.0005041838,0.001049343,0.0000936701,0.0002292051,0.002171455,6.702434e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002649402,"about_ca_system_score_gemma":0.0009335958,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002219367,"about_ca_topic_score_gemma":0.0002714247,"domain_scores_codex":[0.9960256,0.001311145,0.0008555655,0.0007579664,0.0004220051,0.0006276726],"domain_scores_gemma":[0.9920044,0.006923045,0.0001794538,0.0003575551,0.0003101853,0.000225349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02126904,0.0003258651,0.6303958,0.0002785648,0.0008796555,0.00002453822,0.0007793226,0.000005146784,0.008151217,0.00009551015,0.00009026731,0.3377051],"study_design_scores_gemma":[0.01512517,0.002731996,0.9524155,0.001420614,0.000647596,0.0000343579,0.0005924001,0.005525903,0.006685754,0.0006921394,0.01374241,0.000386191],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9244886,0.0148653,0.00001908407,0.0590449,0.0002157845,0.001126057,0.000007757759,0.00003451239,0.0001979831],"genre_scores_gemma":[0.9545139,0.04127136,0.0001268584,0.002619395,0.0003889553,0.0002384375,0.000004977552,0.0000358879,0.0008002283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3373189,"threshold_uncertainty_score":0.9434015,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.11750412329387,"score_gpt":0.5081047822025929,"score_spread":0.3906006589087229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}