{"id":"W4415690663","doi":"10.1007/s00441-025-04020-x","title":"The antioxidant, N-acetyl-L-cysteine, affects beta cell oxidative stress, insulin secretion, and intracellular signaling pathways in MIN6 cells","year":2025,"lang":"en","type":"article","venue":"Cell and Tissue Research","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children’s Health Research Institute; Western University","funders":"Canadian Institutes of Health Research","keywords":"Oxidative stress; Insulin; Antioxidant; Oxidative phosphorylation; Intracellular; Protein kinase B; Fatty acid; Beta cell; Signal transduction; Phosphorylation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00129357,0.0001752932,0.0003210119,0.0002695998,0.0003475568,0.0001150312,0.0001057265,0.0001445293,0.00005341394],"category_scores_gemma":[0.0001699643,0.0001276688,0.00003049245,0.0006241384,0.0003462157,0.00007111787,0.0001392762,0.0005090656,0.00003002949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004771893,"about_ca_system_score_gemma":0.0001681498,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001130677,"about_ca_topic_score_gemma":0.00001882858,"domain_scores_codex":[0.9981307,0.0003543848,0.0002587187,0.0004081095,0.0003600655,0.0004879628],"domain_scores_gemma":[0.9981616,0.001134868,0.0000502407,0.0002893008,0.0001745157,0.0001894866],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001463736,0.0001665317,0.00739257,0.0006946911,0.00002334745,0.00006212199,0.0005023587,0.000005292351,0.9846827,0.0005504719,0.001205371,0.004568166],"study_design_scores_gemma":[0.002030723,0.0006024371,0.002323701,0.000409267,0.00003231506,0.000002851422,0.002001641,0.0007210933,0.9763056,0.0003110193,0.01513355,0.0001257985],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9573225,0.02873796,0.00009748116,0.0006534332,0.00009382091,0.0007298305,0.00001160489,0.00002515418,0.01232814],"genre_scores_gemma":[0.9854249,0.004971593,0.0001669693,0.00004575593,0.00008220091,0.00004159605,0.00002318126,0.00001614889,0.009227687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0281023,"threshold_uncertainty_score":0.5206181,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02214779630342086,"score_gpt":0.2914261594136077,"score_spread":0.2692783631101869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}