{"id":"W4415701428","doi":"10.58931/cht.2025.4s0676","title":"Double-Exposed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma: Clinical Approach and Management","year":2025,"lang":"","type":"article","venue":"Canadian Hematology Today","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Bruton's tyrosine kinase; Chronic lymphocytic leukemia; Lymphocytic infiltration; Ibrutinib; Immunotherapy; Clinical trial; Tyrosine kinase; Lymphoma; Refractory (planetary science)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005842853,0.000358279,0.0004808953,0.0007387653,0.0009361214,0.001401748,0.0007705531,0.0007518489,0.001368752],"category_scores_gemma":[0.001153457,0.0001029143,0.0002076351,0.0008132507,0.0007282645,0.0007851252,0.0009885818,0.001792482,0.0004339729],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003481562,"about_ca_system_score_gemma":0.009715772,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05419912,"about_ca_topic_score_gemma":0.1471086,"domain_scores_codex":[0.9997069,0.00004934147,0.00003106555,0.0000282936,0.0001315554,0.00005269933],"domain_scores_gemma":[0.9995589,0.00003946421,0.00006192507,0.000008692117,0.0001857454,0.0001451999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001138782,0.0000864041,0.01269779,0.002030041,0.00005869176,0.008870305,0.001138154,0.0008008663,0.005461525,0.00662127,0.09947122,0.8626497],"study_design_scores_gemma":[0.0001022868,0.0002684602,0.02322195,0.004498781,0.0001370747,0.04776864,0.00325774,0.0006025925,0.00144328,0.007652196,0.9109543,0.00009272376],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02369922,0.8241203,0.01495752,0.07061659,0.001986653,0.0003963045,0.000329109,0.0003211965,0.06357313],"genre_scores_gemma":[0.1696652,0.7678173,0.02549257,0.02072038,0.004118539,0.0002125311,0.0006761345,0.00007640698,0.01122099],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.05419912,"threshold_uncertainty_score":0.1077673,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03811941451937106,"score_gpt":0.3164352858316126,"score_spread":0.2783158713122415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}