{"id":"W4415703473","doi":"10.1016/j.neuron.2025.09.040","title":"Molecular mechanisms mediating engram ensemble retrievability state in mice","year":2025,"lang":"en","type":"article","venue":"Neuron","topic":"Memory and Neural Mechanisms","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canadian Institute for Advanced Research; University of Toronto; Hospital for Sick Children","funders":"National Institute of Mental Health; National Institutes of Health; Natural Sciences and Engineering Research Council of Canada; Fondation Brain Canada; Ministry of Science and ICT, South Korea; Canadian Institutes of Health Research; National Research Foundation","keywords":"Engram; Optogenetics; Neuroplasticity; Sensory system; Acriflavine; Retrograde amnesia; Sensory memory","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004738839,0.0005674076,0.0003877995,0.000958153,0.000279059,0.00103124,0.00112218,0.0009748998,0.003013019],"category_scores_gemma":[0.0004872608,0.0003837214,0.0004757121,0.0001817526,0.0009162068,0.001147907,0.0006109046,0.002481769,0.0005867659],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004652703,"about_ca_system_score_gemma":0.0002967335,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006231412,"about_ca_topic_score_gemma":0.001033204,"domain_scores_codex":[0.9995412,0.00003645805,0.00004699951,0.0001415061,0.0001089664,0.0001250886],"domain_scores_gemma":[0.9992023,0.00008959678,0.0003632047,0.0001288573,0.000055583,0.0001604628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001520166,0.00003281428,0.0003209315,0.00001892295,0.000009416927,0.0000701343,0.00002564605,0.000155854,0.99617,0.001423496,0.00004168644,0.001579036],"study_design_scores_gemma":[0.00004318199,0.0001800089,0.006888513,0.00002276456,0.00004658568,0.0003072811,0.00007062162,0.003930318,0.9861842,0.001144718,0.001163189,0.00001866592],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9866165,0.0006326849,0.009708869,0.0002634019,0.00005863095,0.0000176957,0.0005514529,0.0003867702,0.001763927],"genre_scores_gemma":[0.9916978,0.0003681769,0.003148703,0.00009178861,0.00001724561,0.00004016936,0.0003350064,0.0001777701,0.004123407],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003013019,"threshold_uncertainty_score":0.01007956,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0359324854566938,"score_gpt":0.3002357756240402,"score_spread":0.2643032901673464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}