{"id":"W4415705479","doi":"10.1172/jci.insight.182711","title":"HIF2α inhibits glutaminase clustering in mitochondria to sustain growth of clear cell renal cell carcinoma","year":2025,"lang":"en","type":"article","venue":"JCI Insight","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Nutrition, Metabolism and Diabetes","funders":"National Institute of Diabetes and Digestive and Kidney Diseases","keywords":"Glutaminase; Mitochondrion; Clear cell renal cell carcinoma; Glutamine; Intracellular; Cell; Cell growth; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001460712,0.0002414113,0.0003436441,0.0001488331,0.0001593965,0.0002477416,0.0002079723,0.0001901084,0.0008041124],"category_scores_gemma":[0.0001025973,0.0001048461,0.0002574143,0.000154628,0.0001435047,0.0001549598,0.0001495254,0.0005338849,0.0003147745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000375954,"about_ca_system_score_gemma":0.0003046932,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001350885,"about_ca_topic_score_gemma":0.002434452,"domain_scores_codex":[0.9998977,0.00001727756,0.00001078547,0.00001867256,0.00002659266,0.00002901654],"domain_scores_gemma":[0.9999336,0.00000741075,0.0000147215,0.00001169485,0.00001180703,0.00002065082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002538247,0.0001069038,0.000183793,0.00004406469,0.00001152646,0.00003434325,0.0000202821,0.0002066858,0.9956543,0.00008531108,0.0002364152,0.003162448],"study_design_scores_gemma":[0.00008017322,0.000737384,0.003514816,0.000006592269,0.00001716954,0.0001919001,0.00003246766,0.002134588,0.9887892,0.00004320276,0.004447529,0.000004929655],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924263,0.002436844,0.002936173,0.0002874417,0.00006585447,0.00005611224,0.000294435,0.0001705701,0.001326372],"genre_scores_gemma":[0.9967037,0.0006417058,0.001012364,0.00006493799,0.000012481,0.00002469641,0.0003388656,0.00002044899,0.00118086],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350885,"threshold_uncertainty_score":0.002727747,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00504446558616298,"score_gpt":0.2190809593328043,"score_spread":0.2140364937466413,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}