{"id":"W4415706476","doi":"10.1016/j.biosystems.2025.105634","title":"Homeostatic set-points are physical and foundational to organism autonomy","year":2025,"lang":"en","type":"article","venue":"Biosystems","topic":"Origins and Evolution of Life","field":"Physics and Astronomy","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Queen's University; Queen's University Belfast","keywords":"Allosteric regulation; Effector; Living systems; Organism; Topology (electrical circuits); Cybernetics; Allosteric enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002017076,0.0005682757,0.000838917,0.001259357,0.001922323,0.005671,0.00135175,0.001739664,0.004058854],"category_scores_gemma":[0.005417581,0.0005387808,0.001022353,0.0005804211,0.01708508,0.006980134,0.004780927,0.003027459,0.001299855],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00148928,"about_ca_system_score_gemma":0.001351128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000726883,"about_ca_topic_score_gemma":0.0004148943,"domain_scores_codex":[0.9975101,0.0005852814,0.0001873881,0.0007479737,0.000707831,0.0002613951],"domain_scores_gemma":[0.9961098,0.001225466,0.0004719634,0.00137227,0.0005402391,0.000280146],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.00001870675,0.00001061873,0.0004239694,0.00007436642,0.00002639257,0.00008983289,0.0005262898,0.00326872,0.001838557,0.9829306,0.0006791155,0.01011275],"study_design_scores_gemma":[0.00001206467,0.00003067504,0.0006485032,0.00003663687,0.00001172654,0.0001272662,0.0001234991,0.002460732,0.001162512,0.9783716,0.01697926,0.00003551837],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.08526054,0.003703276,0.7421486,0.006359111,0.0005915862,0.0001858207,0.0005687287,0.001535106,0.1596473],"genre_scores_gemma":[0.9156755,0.001466064,0.07115193,0.0007819756,0.0004281005,0.0003696555,0.0002985199,0.0002775448,0.009550687],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.005671,"threshold_uncertainty_score":0.01357824,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009497482514034188,"score_gpt":0.2699402508776224,"score_spread":0.2604427683635882,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}