{"id":"W4415712335","doi":"10.1016/j.celrep.2025.116498","title":"In vivo differentiation of embryonic cells devoid of key reprogramming factors","year":2025,"lang":"en","type":"article","venue":"Cell Reports","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Institute of Child Health and Human Development; Canadian Institutes of Health Research; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Surdna Foundation; Human Frontier Science Program; National Institutes of Health; European Molecular Biology Organization","keywords":"Reprogramming; Totipotent; Embryonic stem cell; Cellular differentiation; Cell fate determination; Somatic cell; Transcription factor; Oocyte; Developmental biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001266913,0.00006962647,0.0001172423,0.00006064354,0.00001507745,0.000001874526,0.00003948354,0.000123076,0.00001432085],"category_scores_gemma":[0.00002600498,0.0000655354,0.00005044593,0.00009469345,0.00003678873,0.00000225194,0.00004575444,0.00002891953,2.141872e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001015148,"about_ca_system_score_gemma":0.00006038511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001760616,"about_ca_topic_score_gemma":0.00002736179,"domain_scores_codex":[0.9993488,0.00002413005,0.0002952982,0.0001965136,0.00004690545,0.0000883413],"domain_scores_gemma":[0.999551,0.000006988787,0.0001990644,0.0001914831,0.0000379817,0.00001347349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001279011,0.00004764855,0.1441022,0.00004330922,0.00001261616,0.00000223081,0.00003823693,0.00002737445,0.8551437,0.000007527566,0.0001730815,0.0003893476],"study_design_scores_gemma":[0.00009898443,0.00003038175,0.06148826,0.00001557201,0.000007465208,0.000001796641,0.00003863385,0.000004072725,0.935346,0.00009447501,0.002822808,0.00005156856],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974809,0.0003230615,0.0003229109,0.00000922167,0.0002521472,0.0001091318,0.000001376569,0.000002622491,0.001498597],"genre_scores_gemma":[0.9971704,0.00004356958,0.0002379359,0.000009465952,0.00000779265,0.000004162071,0.00005971697,0.000003618335,0.002463294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08261394,"threshold_uncertainty_score":0.2672456,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004753308261430892,"score_gpt":0.226268790275349,"score_spread":0.2215154820139181,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}