{"id":"W4415721093","doi":"10.3389/fmolb.2025.1681647","title":"RNA-based therapies for neurodevelopmental disorders: innovative tools for molecular correction","year":2025,"lang":"en","type":"review","venue":"Frontiers in Molecular Biosciences","topic":"Genetics and Neurodevelopmental Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; European Commission","keywords":"Rett syndrome; Fragile X syndrome; Angelman syndrome; RNA; CRISPR; RNA interference; Autism; Non-coding RNA; Autism spectrum disorder","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003454895,0.0006219568,0.0008455916,0.0005563689,0.0001952098,0.0001673626,0.000793284,0.000513435,0.000001703311],"category_scores_gemma":[0.0005168157,0.0005927772,0.0004639102,0.001158947,0.0002808136,0.00001334045,0.0001532932,0.0002148102,5.765405e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007227454,"about_ca_system_score_gemma":0.001156579,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003764842,"about_ca_topic_score_gemma":0.00001551091,"domain_scores_codex":[0.997117,0.0001454872,0.0006454022,0.001239992,0.0002601253,0.0005919474],"domain_scores_gemma":[0.9990296,0.00007573427,0.0003103146,0.0003777414,0.0001375544,0.00006909117],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005808304,0.0001471985,0.00004606724,0.002267791,0.0001415838,0.000002240549,0.00002955691,0.00008526035,0.006267183,0.0000600493,0.005619421,0.9852756],"study_design_scores_gemma":[0.0008372893,0.0005275179,0.00005107748,0.001319882,0.0001179674,0.000001845403,0.0002126667,0.0001581738,0.01071262,0.0003069016,0.9847834,0.0009707228],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003140662,0.7499453,0.2430778,0.0001013671,0.003005387,0.003113816,0.0001831508,0.00001933972,0.0002397369],"genre_scores_gemma":[0.001024949,0.9405015,0.05359546,0.0008042068,0.00002460136,0.002213177,0.00142165,0.00009070884,0.0003237282],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9843048,"threshold_uncertainty_score":0.9996524,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0152887059594708,"score_gpt":0.2885984915201224,"score_spread":0.2733097855606516,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}