{"id":"W4415724813","doi":"10.1002/advs.202514388","title":"The Circadian Transcription Factor CLOCK Modulates Oxidative Stress Resistance via the ACHL– <i>Relish</i> Axis in Drosophila","year":2025,"lang":"en","type":"article","venue":"Advanced Science","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Key Technologies Research and Development Program; Natural Science Research of Jiangsu Higher Education Institutions of China; National Institutes of Health; Ministry of Science and Technology of the People's Republic of China; National Natural Science Foundation of China","keywords":"Circadian clock; Transcription factor; Effector; Innate immune system; Immune system; Oxidative stress; Circadian rhythm; Regulator","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.0004964844,0.0002214783,0.000180842,0.0001750914,0.001497625,0.0002582752,0.001307741,0.00006440917,0.00000696353],"category_scores_gemma":[0.0008949314,0.0001469031,0.00007390107,0.002707424,0.001767988,0.001011034,0.00009279647,0.0004296904,0.0000244146],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002113336,"about_ca_system_score_gemma":0.0002424066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002757849,"about_ca_topic_score_gemma":0.0004805659,"domain_scores_codex":[0.9973434,0.0001476881,0.0003518589,0.000848048,0.0005568959,0.0007520972],"domain_scores_gemma":[0.9982301,0.0006657299,0.0001231355,0.0007658063,0.00008856004,0.0001266633],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004741842,0.00003629616,0.0007235177,0.00001068993,0.00000151852,0.000009089135,0.001470098,0.0008140288,0.9164034,0.07130077,0.00003215144,0.00915108],"study_design_scores_gemma":[0.0004579801,0.00002808814,0.05421977,0.0001131106,0.000004453119,0.000004516681,0.0003679477,0.001115715,0.9177678,0.01135713,0.0143228,0.0002407525],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9825928,0.001852771,0.001316354,0.005631242,0.001212745,0.0008029557,0.00005078112,0.00009296216,0.006447351],"genre_scores_gemma":[0.9963096,0.0004299098,0.0001093697,0.001058631,0.00003346568,0.00008174294,8.368269e-7,0.00001231713,0.001964141],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05994365,"threshold_uncertainty_score":0.9998023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0132267138209478,"score_gpt":0.2606659886575011,"score_spread":0.2474392748365533,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}