{"id":"W4415725407","doi":"10.1038/s41398-025-03661-4","title":"De novo variant analysis of childhood-onset obsessive-compulsive disorder in the French-Canadian population","year":2025,"lang":"en","type":"article","venue":"Translational Psychiatry","topic":"Obsessive-Compulsive Spectrum Disorders","field":"Psychology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Université de Montréal; Centre Hospitalier Universitaire Sainte-Justine; McGill University; Montreal Neurological Institute and Hospital","funders":"CIHR Skin Research Training Centre; Fonds de Recherche du Québec-Société et Culture; Government of Canada; ALS Society of Canada","keywords":"Proband; Gene; Candidate gene; Schizophrenia (object-oriented programming); Single-nucleotide polymorphism; Genetic association; Population; Genetic heterogeneity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006120565,0.0007986226,0.0005453424,0.002762623,0.002972635,0.001144322,0.0008920429,0.0007609291,0.00372714],"category_scores_gemma":[0.001763258,0.0002510479,0.0009576999,0.002893782,0.0006544355,0.0001704773,0.0007427279,0.0005839223,0.0002366134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.005249082,"about_ca_system_score_gemma":0.006005019,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.9316889,"about_ca_topic_score_gemma":0.9179933,"domain_scores_codex":[0.9992106,0.00006282415,0.0000439873,0.0002816372,0.0002203742,0.0001805795],"domain_scores_gemma":[0.9992224,0.00009725147,0.0001363966,0.00005119024,0.000320232,0.0001725327],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004786423,0.00005420013,0.9654371,0.000101484,0.0004001945,0.002769004,0.002010038,0.0004433393,0.005889953,0.0008556516,0.002167437,0.01939297],"study_design_scores_gemma":[0.0000243529,0.00006449354,0.9907679,0.00005212814,0.0001755196,0.002614352,0.001024512,0.0005988186,0.0004814635,0.000117508,0.004039505,0.00003938417],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932701,0.001420796,0.0006074109,0.000283977,0.00002703882,0.00003956879,0.002519255,0.00002550806,0.001806431],"genre_scores_gemma":[0.9964715,0.000776009,0.0005695421,0.0001242273,0.00001293358,0.00001431536,0.001040591,0.0000130649,0.0009777213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0683111,"threshold_uncertainty_score":0.1374267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006884153796892923,"score_gpt":0.282714151663482,"score_spread":0.275829997866589,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}