{"id":"W4415731592","doi":"10.1038/s44318-025-00600-3","title":"Concurrence of FGFR1 mutations modulates oncogenesis in glioneuronal tumors","year":2025,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; University of Toronto; Université de Montréal; McGill University; McGill Genome Centre; Sinai Health System; Montreal Clinical Research Institute; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"Fonds de Recherche du Québec - Santé; Fonds de recherche du Québec; Agència de Gestió d'Ajuts Universitaris i de Recerca; Generalitat de Catalunya; Spanish National Plan for Scientific and Technical Research and Innovation; “la Caixa” Foundation; Ministerio de Ciencia e Innovación; Instituto de Salud Carlos III; Canadian Cancer Society Research Institute; Canadian Institutes of Health Research; Alex's Lemonade Stand Foundation for Childhood Cancer","keywords":"Oligodendroglioma; Carcinogenesis; Missense mutation; Fibroblast growth factor receptor 1; Phenotype; Mutation; Interactome; Context (archaeology); Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002853321,0.0000696731,0.00009250721,0.00009718107,0.00007911101,0.00001847156,0.0002844819,0.00003328569,0.00002911688],"category_scores_gemma":[0.0001817254,0.00005102998,0.00006071897,0.0002056279,0.0001320489,0.000003734713,0.00009539739,0.0001807601,0.000003499823],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001504602,"about_ca_system_score_gemma":0.0002121559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001444216,"about_ca_topic_score_gemma":0.00001499526,"domain_scores_codex":[0.9992395,0.0001307069,0.000217672,0.0001050404,0.000144181,0.0001628956],"domain_scores_gemma":[0.9995978,0.00004719087,0.00006819929,0.0001487982,0.0001016871,0.00003629896],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009399435,0.00006041486,0.02584197,0.00001979764,0.00004431101,0.00001018301,0.00008969755,0.001834926,0.9690019,0.0003648138,0.0006943892,0.00194358],"study_design_scores_gemma":[0.0008953212,0.0002557947,0.1719427,0.0001361312,0.00001708208,0.0001662786,0.0002535646,0.0009252962,0.8217183,0.00235921,0.001189454,0.0001408296],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978624,0.0004758474,0.0004597846,0.0004434549,0.00009002446,0.00007167978,0.00000839631,0.000001928943,0.000586462],"genre_scores_gemma":[0.9995312,0.00006533424,0.00008266549,0.00004543122,0.00005083678,0.000003945648,0.000005518181,0.000005842463,0.0002091889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1472836,"threshold_uncertainty_score":0.2080942,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01182254175989615,"score_gpt":0.2996253224043849,"score_spread":0.2878027806444888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}