{"id":"W4415736166","doi":"10.1128/aac.00478-25","title":"Vacuolar-ATPase inhibitors are antimicrobial agents active against intracellular mycobacteria","year":2025,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Cystic Fibrosis Canada","keywords":"Bafilomycin; Intracellular; Phagosome; Intracellular parasite; Antimicrobial; Axenic; Cytotoxicity; Bacteria; Phagocytosis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001404897,0.0003909408,0.0003528532,0.0001252617,0.0003135717,0.0001482137,0.0003165935,0.0003324149,0.0001150509],"category_scores_gemma":[0.000028813,0.0003753603,0.0001969416,0.0002189217,0.0002039449,0.00002109535,0.0002456277,0.0002252946,0.0000250079],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003493774,"about_ca_system_score_gemma":0.0001105988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004457796,"about_ca_topic_score_gemma":0.00001728574,"domain_scores_codex":[0.9981089,0.0000940618,0.0003502838,0.0007340626,0.0001502177,0.0005624322],"domain_scores_gemma":[0.9991468,0.0000124565,0.0001470889,0.0004257786,0.0001145556,0.0001533012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004426081,0.000321207,0.01327072,0.00007938216,0.000290004,0.00003556538,0.00007880548,0.000004736636,0.8216982,0.000007992425,0.1521646,0.01160619],"study_design_scores_gemma":[0.001964321,0.00008119504,0.01204807,0.0001366626,0.00002925633,0.00000494717,0.00007509618,0.00003341113,0.7362887,0.000009111747,0.2489556,0.0003736659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954634,0.00008297431,0.000212901,0.002553581,0.000399395,0.00043215,0.0001616711,0.00003281116,0.0006611316],"genre_scores_gemma":[0.9807189,0.003480914,0.0001731626,0.01252176,0.0004283869,0.00001322976,0.0003937231,0.00005706198,0.002212883],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09679102,"threshold_uncertainty_score":0.9998698,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00877655038714006,"score_gpt":0.2676388782751769,"score_spread":0.2588623278880368,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}