{"id":"W4415757151","doi":"10.1101/2025.10.30.685603","title":"Rationally designed minimized TbpB confers broad protection against meningococcal infection","year":2025,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Bacterial Infections and Vaccines","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Armand Frappier Museum; University of Toronto","funders":"Common Fund; Argonne National Laboratory; National Institute of General Medical Sciences; Office of Science; National Institutes of Health; University of Toronto; U.S. Department of Energy","keywords":"Immunogen; Immune system; Antigen; Meningococcal vaccine; Antigenic variation; Neisseria meningitidis; Epitope; Meningococcal disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001230638,0.0002846544,0.0001796612,0.0000978634,0.0001097803,0.0002173858,0.0001790399,0.000156829,0.0006953143],"category_scores_gemma":[0.0001722942,0.00009489055,0.0001173221,0.00008143168,0.0001728496,0.0001092403,0.0002044765,0.0003591111,0.0002225116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002347763,"about_ca_system_score_gemma":0.000240012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005540589,"about_ca_topic_score_gemma":0.0009098302,"domain_scores_codex":[0.9999402,0.00001034259,0.000004343226,0.00001091448,0.00001714681,0.00001713112],"domain_scores_gemma":[0.9999436,0.000008359091,0.00001590421,0.000005643291,0.00001129321,0.00001523013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000108808,0.00005993917,0.000224808,0.00002402743,0.000005815331,0.00005751631,0.00001111805,0.001002148,0.9969235,0.000220508,0.00006545681,0.001296244],"study_design_scores_gemma":[0.00003745908,0.0005431445,0.001282208,0.000008824823,0.00001481095,0.0001754376,0.00002030769,0.006697332,0.9888837,0.00006482325,0.002264416,0.000007497884],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949124,0.0002065566,0.003852813,0.00005327581,0.0000115019,0.00002569237,0.00006924383,0.00004375437,0.0008247911],"genre_scores_gemma":[0.9960557,0.0001423319,0.002981921,0.00004174073,0.000002879662,0.00001573322,0.0001325097,0.00001422264,0.0006129124],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006953143,"threshold_uncertainty_score":0.002326071,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01748826526604833,"score_gpt":0.2303725050458645,"score_spread":0.2128842397798161,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}