{"id":"W4415763164","doi":"10.1101/2025.10.28.685139","title":"Structural basis for substrate specificity and MSMEG_0435-0436 binding by the mycobacterial long-chain acyl-CoA carboxylase complex","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Biotin and Related Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Pyruvate carboxylase; Acetyl-CoA carboxylase; Biotin; Protein subunit; Acyl carrier protein; Enzyme; Substrate (aquarium); Binding site; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity"],"consensus_categories":["metaepi_narrow"],"category_scores_codex":[0.0009814375,0.001495591,0.001239053,0.0001875352,0.001485644,0.0005306061,0.001006941,0.001915448,0.00005075779],"category_scores_gemma":[0.0003684515,0.001275945,0.0005258911,0.0004755137,0.001063002,0.00002145408,0.001434084,0.001210601,0.000007288111],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002190173,"about_ca_system_score_gemma":0.0006666959,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001003676,"about_ca_topic_score_gemma":0.00003265806,"domain_scores_codex":[0.9941972,0.0004291433,0.001224367,0.002384436,0.0003951666,0.001369662],"domain_scores_gemma":[0.9961678,0.0002008947,0.0008636959,0.00162742,0.0007205295,0.000419638],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005924791,0.0001067915,0.005314454,0.0008119222,0.001633173,0.00001453133,0.00003001751,0.00002541598,0.9890938,0.0003032511,0.002055598,0.00001852435],"study_design_scores_gemma":[0.002584339,0.0003368475,0.04255012,0.0005337925,0.0009113661,2.807019e-7,0.00005436047,0.0006434946,0.9186507,0.000001853869,0.03168165,0.002051148],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784494,0.007293977,0.0006545866,0.0009247407,0.00389101,0.002344768,0.00631306,0.0000937763,0.00003470359],"genre_scores_gemma":[0.9907688,0.005871858,0.001067115,0.0002869886,0.001516624,0.0002244272,0.00002235585,0.0001392641,0.0001025059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07044309,"threshold_uncertainty_score":0.9998143,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01624501785058129,"score_gpt":0.231879078152496,"score_spread":0.2156340603019147,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}