{"id":"W4415779737","doi":"10.1101/2025.11.01.686071","title":"Fission yeast histone chaperone Rtt106 regulates histone levels, prevents early division, and promotes genome stability","year":2025,"lang":"","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Histone H2A; Histone H1; Histone code; Chromatin; Histone methylation; Histone; Histone methyltransferase; Chromatin remodeling; Histone H3","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005090507,0.0002527433,0.0002050335,0.0001093907,0.000123279,0.0002570378,0.0001639428,0.0001777943,0.001104147],"category_scores_gemma":[0.00008181705,0.00009435746,0.0001865284,0.0001476657,0.0001304946,0.0001198024,0.0001523017,0.0003612553,0.0004354917],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002245037,"about_ca_system_score_gemma":0.0001185282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005252823,"about_ca_topic_score_gemma":0.0006636253,"domain_scores_codex":[0.9999287,0.000004939383,0.000007218384,0.00001990655,0.00002629407,0.00001278574],"domain_scores_gemma":[0.999897,0.000009876139,0.00004173054,0.00001338668,0.00001109044,0.00002696033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005689821,0.000006344491,0.000141524,0.0000118935,0.000001686887,0.00003665086,0.000002157195,0.00005449813,0.9992198,0.00002066067,0.00004074619,0.0004071205],"study_design_scores_gemma":[0.000007994472,0.00004199011,0.003197916,0.000002594517,0.000004062757,0.0001395537,0.000006008467,0.0005761561,0.9949355,0.00001904457,0.001066488,0.000002812059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952847,0.0007596476,0.001821501,0.00009867588,0.00003214391,0.000006984263,0.0009418524,0.0001784885,0.0008760146],"genre_scores_gemma":[0.9949903,0.0003051288,0.001161437,0.0000396412,0.000006769288,0.000006104005,0.001383543,0.00006886155,0.002038235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001104147,"threshold_uncertainty_score":0.003693759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01059210688342939,"score_gpt":0.2260224059197957,"score_spread":0.2154302990363664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}