{"id":"W4415780093","doi":"10.30574/ijsra.2025.17.1.2929","title":"Lecanemab, Donanemab, and Emerging Disease Modifying Therapies for Alzheimer Disease: Clinical Evidence and Primary Care Implications in Canada","year":2025,"lang":"","type":"article","venue":"International Journal of Science and Research Archive","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Reimbursement; Disease; Health care; Clinical trial; Dementia; Narrative review; Randomized controlled trial; Cognitive decline","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.005007436,0.0001659935,0.000321405,0.001353267,0.0006631284,0.0003402128,0.0006759448,0.00002666955,0.00001546028],"category_scores_gemma":[0.003732601,0.0001322498,0.00007454045,0.0006066514,0.003624742,0.0007082206,0.000740584,0.0007204891,3.173035e-7],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005986667,"about_ca_system_score_gemma":0.0240683,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01785978,"about_ca_topic_score_gemma":0.0154932,"domain_scores_codex":[0.9953701,0.0003454069,0.0007614471,0.00055849,0.002328279,0.0006362276],"domain_scores_gemma":[0.9917822,0.003035539,0.0001817443,0.0001748048,0.003831909,0.0009938049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.002491909,0.0001745866,0.7174106,0.0003793747,0.0002451992,0.0002362648,0.001269628,0.000005705569,0.001720944,0.001163948,0.0004541593,0.2744477],"study_design_scores_gemma":[0.00199781,0.0002900225,0.979721,0.003682106,0.0001232264,0.00002560688,0.005779456,0.001498259,0.00009107408,0.005036097,0.001638851,0.0001164845],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8937402,0.0705773,0.0003159481,0.03357045,0.0003851014,0.0009957276,0.0001276437,0.000001862339,0.0002857741],"genre_scores_gemma":[0.9539156,0.04474771,0.0004265245,0.0005550743,0.0001964652,0.00005208207,0.000007301488,0.00000779777,0.00009146787],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2743312,"threshold_uncertainty_score":0.9990868,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0874086059526393,"score_gpt":0.4728657140857103,"score_spread":0.385457108133071,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}