{"id":"W4415781242","doi":"10.1113/jp288819","title":"<i>In silico</i> predictions of action potential propagation in doxorubicin cardiotoxicity: A parametric study using preclinical 3D magnetic resonance imaging‐based fibrotic left ventricle models","year":2025,"lang":"en","type":"article","venue":"The Journal of Physiology","topic":"Chemotherapy-induced cardiotoxicity and mitigation","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Hospital","funders":"European Social Fund; European Regional Development Fund; Barcelona Supercomputing Center; Agencia Estatal de Investigación; Agence Nationale de la Recherche; Canadian Institutes of Health Research; European Commission","keywords":"Ventricle; Action potential; Parametric statistics; Magnetic resonance imaging; Cardiotoxicity; Doxorubicin; Computational model; Nerve conduction velocity","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002120986,0.0003716803,0.000311109,0.0002951231,0.0001833052,0.0005961574,0.0005460018,0.0008257102,0.0008515007],"category_scores_gemma":[0.0008193182,0.0001940919,0.0004783928,0.00014978,0.0004118999,0.0002341908,0.0003166645,0.0003075823,0.0001243466],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003475402,"about_ca_system_score_gemma":0.0004096153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00406024,"about_ca_topic_score_gemma":0.002144859,"domain_scores_codex":[0.9999393,0.00001824753,0.000004143624,0.000008504907,0.00001719072,0.00001253071],"domain_scores_gemma":[0.9995878,0.0002635934,0.00006404929,0.00002575329,0.0000387866,0.0000200131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.00002842205,0.00003134182,0.0007174141,0.00002112002,0.000008296743,0.00007912509,0.00002311078,0.9916962,0.005836369,0.0004183756,0.00006701619,0.001073414],"study_design_scores_gemma":[0.000003603022,0.00002039856,0.0001959589,0.000002439946,0.000003041964,0.00001444623,0.000004534891,0.9985892,0.0009818082,0.00009540378,0.00008637569,0.000002849412],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.90688,0.0003499931,0.08371876,0.0003325676,0.00004139982,0.00007847941,0.0003722216,0.0002388667,0.007987723],"genre_scores_gemma":[0.9910238,0.000170522,0.007732267,0.00004229266,0.000008308357,0.00005223204,0.0001181257,0.00002868457,0.0008238482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00406024,"threshold_uncertainty_score":0.008073211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03110288363622996,"score_gpt":0.3279019366331927,"score_spread":0.2967990529969627,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}