{"id":"W4415785722","doi":"10.1021/acs.molpharmaceut.5c01417","title":"Drug Delivery Strategies to Cross, Target, or Bypass the Blood–Brain Barrier","year":2025,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Barrie Urology Group","funders":"","keywords":"Drug delivery; Drug; Targeted drug delivery; MEDLINE; Delivery system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002405733,0.0002667317,0.000204454,0.000105781,0.0006387495,0.0003369834,0.0005423104,0.00006443444,0.0001981385],"category_scores_gemma":[0.0003716794,0.0001778612,0.0001134901,0.0007741161,0.0002778606,0.0001510702,0.0003423969,0.0003670193,0.00005526776],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002949425,"about_ca_system_score_gemma":0.0002209117,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001341494,"about_ca_topic_score_gemma":0.00001418791,"domain_scores_codex":[0.9981688,0.0002167604,0.0002777938,0.0004945166,0.0003503205,0.0004917702],"domain_scores_gemma":[0.9989612,0.0002928558,0.00005726425,0.0004417842,0.0001024047,0.0001445587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002091252,0.00005067257,0.0004830039,0.00004606987,0.0001470223,0.0002135531,0.001044587,0.001191144,0.9485232,0.01089118,0.03518862,0.00201179],"study_design_scores_gemma":[0.0004299205,0.00001910857,0.0001159967,0.000007282836,0.00007078175,0.0000107955,0.000225788,0.0002264265,0.5963582,0.001197756,0.4011809,0.0001570294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9198722,0.002632031,0.01933276,0.01905399,0.003915885,0.001301373,0.0001583362,0.0004298451,0.03330364],"genre_scores_gemma":[0.9365591,0.0001020721,0.0003175179,0.05388918,0.00009258777,0.00006256327,0.000001770137,0.00002609161,0.008949134],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3659922,"threshold_uncertainty_score":0.7252969,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02818322987411631,"score_gpt":0.3445039184740919,"score_spread":0.3163206885999756,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}