{"id":"W4415789305","doi":"10.1161/circ.152.suppl_3.4364102","title":"Abstract 4364102: Acoramidis Reduces All-Cause Mortality and Cardiovascular-Related Hospitalizations Through Month 42 in Transthyretin Amyloid Cardiomyopathy Across All Pre-specified Patient Subgroups","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Transthyretin; Placebo; Heart failure; Randomization; Cardiomyopathy; Clinical trial; Risk stratification; Subgroup analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007858187,0.0005186927,0.00170149,0.000298181,0.0002500682,0.0005732715,0.0003241984,0.0006728035,0.005352834],"category_scores_gemma":[0.0009767946,0.0001915354,0.001225248,0.0002902544,0.0002262158,0.0003541545,0.000279945,0.0009584781,0.0005553973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002135853,"about_ca_system_score_gemma":0.0006596213,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000611788,"about_ca_topic_score_gemma":0.001918035,"domain_scores_codex":[0.9997081,0.0001216926,0.00002482293,0.00004699952,0.00005222933,0.00004623147],"domain_scores_gemma":[0.9995089,0.0001024147,0.0001491834,0.00004555749,0.00004957014,0.0001444576],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.7944391,0.009221852,0.01348946,0.001344988,0.002066834,0.0001173113,0.0001289461,0.0005226874,0.04228151,0.0001101796,0.003574926,0.1327022],"study_design_scores_gemma":[0.3962654,0.3161719,0.2670446,0.0002919848,0.003506919,0.0005331751,0.0001810297,0.001516296,0.009926531,0.0004587533,0.004033836,0.00006955085],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930015,0.003777954,0.0001866304,0.0003238667,0.00008631755,0.0003526038,0.0008413644,0.00007784291,0.001352086],"genre_scores_gemma":[0.9939744,0.001800462,0.000579437,0.0004209641,0.0001641364,0.0003014828,0.0009071573,0.00001158382,0.001840354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005352834,"threshold_uncertainty_score":0.01790696,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02499966484265949,"score_gpt":0.29984115836175,"score_spread":0.2748414935190905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}