{"id":"W4415789318","doi":"10.1161/circ.152.suppl_3.4361033","title":"Abstract 4361033: Cardiac RBFOX1 Deficiency Enhances Glucose and Ketone Metabolism and Provides Tolerance Against Ischemia Reperfusion Injury","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Ischemia and Reperfusion","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Ketone bodies; Heart failure; Ischemia; Reperfusion injury; Aestivation; Intracellular; 4-Hydroxynonenal","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001779924,0.000499396,0.0003829313,0.0003520566,0.0002316241,0.0003244671,0.0003404136,0.0005079661,0.007866407],"category_scores_gemma":[0.000090343,0.0002061001,0.0003618132,0.0002103956,0.0004097859,0.000265679,0.0002466024,0.0008323574,0.001166852],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003156556,"about_ca_system_score_gemma":0.0002800841,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009702773,"about_ca_topic_score_gemma":0.001378792,"domain_scores_codex":[0.9998251,0.00001533413,0.00002351463,0.00004909359,0.00004759889,0.00003954985],"domain_scores_gemma":[0.9997795,0.00001456735,0.00007965594,0.00001422127,0.00001868025,0.00009335851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004916239,0.00003891304,0.0002415966,0.00008554172,0.00000595691,0.00006877563,0.00001366586,0.00002845728,0.9976352,0.00009938271,0.0001355634,0.001155321],"study_design_scores_gemma":[0.0002879761,0.001467118,0.02160964,0.00005369314,0.00007215232,0.0009496058,0.0001347815,0.0008770198,0.967088,0.0001123075,0.007331022,0.00001672973],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9870045,0.001337808,0.003476632,0.0003652726,0.0001031347,0.00007249727,0.003622916,0.000436699,0.003580641],"genre_scores_gemma":[0.9713815,0.001240438,0.002877786,0.0002015969,0.00004515865,0.0001582009,0.003781122,0.0001519811,0.02016208],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007866407,"threshold_uncertainty_score":0.02631575,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006585102471262699,"score_gpt":0.2543792936622606,"score_spread":0.2477941911909979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}