{"id":"W4415789695","doi":"10.1007/978-1-0716-4848-3_15","title":"Identifying Trypanosoma cruzi Proteins Targeted by Chagas Disease Patient Antibodies Using Yeast Surface Display","year":2025,"lang":"en","type":"article","venue":"Methods in molecular biology","topic":"Trypanosoma species research and implications","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University Health Centre; McGill University","funders":"","keywords":"Trypanosoma cruzi; Saccharomyces cerevisiae; Chagas disease; Yeast; Antibody; Pathogen; Antigen; Sorting; Cell sorting","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001824652,0.0004715444,0.0003693699,0.0002633937,0.0001787786,0.0006114239,0.0003112968,0.0004334784,0.001472642],"category_scores_gemma":[0.0002589624,0.0001837439,0.0003583055,0.0002704425,0.0001434244,0.000202061,0.0004400426,0.0006963853,0.0006575493],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002878593,"about_ca_system_score_gemma":0.00009824103,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005127093,"about_ca_topic_score_gemma":0.000765653,"domain_scores_codex":[0.999827,0.00003277954,0.00000888096,0.00003334102,0.00004815299,0.000049858],"domain_scores_gemma":[0.9999256,0.00002500359,0.00001011118,0.000009361052,0.00001883505,0.00001110658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005948335,0.00001421491,0.0002886307,0.00002085073,0.000007692473,0.00004378121,0.00001768571,0.00008744829,0.9975612,0.0001174072,0.00006290633,0.001718671],"study_design_scores_gemma":[0.00001145714,0.0001344553,0.002860882,0.000004352159,0.00002251837,0.0003822053,0.00005655095,0.003781071,0.9900539,0.00009501098,0.002591918,0.00000564946],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"methods","genre_scores_codex":[0.9628918,0.001098514,0.03158669,0.0002113477,0.00003989516,0.0000640812,0.000378748,0.0002144259,0.003514468],"genre_scores_gemma":[0.9818479,0.0007257834,0.01323756,0.000114451,0.000009687144,0.00003314262,0.000770358,0.00004485505,0.003216266],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.001472642,"threshold_uncertainty_score":0.004926503,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03650011552027735,"score_gpt":0.4439860955835596,"score_spread":0.4074859800632822,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}