{"id":"W4415789851","doi":"10.1161/circ.152.suppl_3.4367120","title":"Abstract 4367120: Impact of Aortic Valve Calcification on Functional Valve Area and Cardiac Structure and Function in a Phase 2 Trial of Ataciguat","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec","funders":"","keywords":"valvular heart disease; Placebo; Aortic valve; Stenosis; Cardiac function curve; Calcification; Diastole; Aortic valve stenosis; Heart failure","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00201123,0.001901994,0.00275191,0.0003875598,0.0004010161,0.001247508,0.0009014613,0.001632542,0.0073379],"category_scores_gemma":[0.001581923,0.0006111119,0.001445332,0.0003652523,0.0008183347,0.0007205427,0.0003833568,0.003648054,0.0009294022],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005634991,"about_ca_system_score_gemma":0.001134588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006715648,"about_ca_topic_score_gemma":0.001622178,"domain_scores_codex":[0.999441,0.0003170255,0.0000249357,0.00008445023,0.00004655089,0.00008608079],"domain_scores_gemma":[0.9992112,0.0001845847,0.0001936537,0.00005740438,0.00007269775,0.0002804752],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.9499524,0.01614143,0.001364792,0.0007064514,0.001370625,0.0000599766,0.00006849516,0.0003884286,0.005216809,0.000173162,0.002269974,0.02228748],"study_design_scores_gemma":[0.9004915,0.09399991,0.003675845,0.00003432013,0.000395684,0.00003937521,0.00002130179,0.0004214027,0.0003043487,0.0001415537,0.0004602775,0.00001451066],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886553,0.003857815,0.0003958129,0.0009786109,0.0003578431,0.002086573,0.001268773,0.0002025036,0.002196782],"genre_scores_gemma":[0.9867272,0.001837463,0.001410428,0.001413949,0.0004404828,0.003523791,0.001831624,0.00003693971,0.002778162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0073379,"threshold_uncertainty_score":0.0245477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02308296380124368,"score_gpt":0.3551597102000836,"score_spread":0.3320767463988399,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}