{"id":"W4415789992","doi":"10.1007/s10522-025-10345-5","title":"Liu Jun Zi Decoction extends lifespan and healthspan through p16/p21 signaling in Caenorhabditis elegans","year":2025,"lang":"en","type":"article","venue":"Biogerontology","topic":"Genetics, Aging, and Longevity in Model Organisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Aging","funders":"National Natural Science Foundation of China","keywords":"Caenorhabditis elegans; Longevity; Neuroprotection; Decoction; Model organism; Function (biology)","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001574709,0.0003806061,0.0003533209,0.0003618183,0.0002436202,0.0002374946,0.0002713866,0.000340572,0.002581481],"category_scores_gemma":[0.00009378721,0.0001430467,0.0002737827,0.0001341516,0.0004236161,0.0002762993,0.0002120541,0.0007598121,0.0003075829],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002850305,"about_ca_system_score_gemma":0.0004032566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001647968,"about_ca_topic_score_gemma":0.003757818,"domain_scores_codex":[0.9998865,0.000007327428,0.00001223169,0.00002925233,0.00003098915,0.00003360891],"domain_scores_gemma":[0.9999192,0.000004463783,0.00002710801,0.000007169974,0.000009149466,0.00003294045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003599573,0.00006006565,0.0002475834,0.0001145421,0.00001292116,0.00005654039,0.00001754773,0.00007902343,0.9957086,0.0002006185,0.0002174126,0.002925164],"study_design_scores_gemma":[0.000279447,0.001289079,0.01271932,0.00002710442,0.0001167472,0.0002238238,0.0001093812,0.001928331,0.9742304,0.0002264615,0.008824374,0.00002551339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930039,0.002307385,0.00141567,0.0002704827,0.000134294,0.00002943232,0.0005356008,0.0001820547,0.002121194],"genre_scores_gemma":[0.9904004,0.001593241,0.0009498963,0.000152186,0.00002106846,0.00004888834,0.0003732023,0.00002650748,0.006434607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002581481,"threshold_uncertainty_score":0.008635879,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01059334612677051,"score_gpt":0.2769710532215451,"score_spread":0.2663777070947747,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}