{"id":"W4415790481","doi":"10.1038/s44318-025-00603-0","title":"Tyrosine kinase targeting uncovers oncogenic pathway plasticity in Tasmanian devil transmissible cancers","year":2025,"lang":"en","type":"article","venue":"The EMBO Journal","topic":"Veterinary Oncology Research","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Amgen (Canada); University of Toronto","funders":"Veterinärmedizinische Universität Wien","keywords":"ErbB; Kinase; Tyrosine kinase; Receptor tyrosine kinase; Signal transduction; Phosphorylation; Signalling; Cancer cell; Acquired resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001042212,0.0001572674,0.0003359857,0.0002521943,0.0002955899,0.00003856278,0.0002760537,0.00008541435,0.000479001],"category_scores_gemma":[0.0003320317,0.000107064,0.0001203238,0.0005523804,0.0001656252,0.00009527433,0.00006105166,0.001211314,0.00002516982],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000991166,"about_ca_system_score_gemma":0.00190025,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001611983,"about_ca_topic_score_gemma":0.0002369939,"domain_scores_codex":[0.9983007,0.0002558073,0.0003969694,0.0001913489,0.0003353048,0.0005198825],"domain_scores_gemma":[0.9992113,0.0002432002,0.00008635328,0.0001609623,0.0001082826,0.0001899387],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01076356,0.0009509616,0.1046926,0.0006733457,0.0009037731,0.01274085,0.005071801,0.006552884,0.7686765,0.0007655757,0.03516909,0.05303906],"study_design_scores_gemma":[0.07781919,0.01528098,0.2613509,0.009607686,0.001728636,0.04246136,0.01732388,0.02884017,0.1336256,0.008267383,0.401119,0.002575258],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852974,0.001394464,0.0007966075,0.006679974,0.0003760478,0.0002783721,0.000006412757,0.00002305327,0.005147598],"genre_scores_gemma":[0.9960366,0.0003100248,0.0007577743,0.0006642247,0.0002346139,0.00001219175,0.000002813089,0.00001816808,0.001963611],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6350509,"threshold_uncertainty_score":0.5262624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02931472240078192,"score_gpt":0.3330046949648071,"score_spread":0.3036899725640251,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}