{"id":"W4415791610","doi":"10.1161/circ.152.suppl_3.4364377","title":"Abstract 4364377: An Integrative Strategy Combining Genetic, Proteomic, and Clinical Data Identifies Circulating WARS as a Candidate Target for Hypertension.","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Heart Institute","funders":"","keywords":"Mendelian randomization; Biobank; Genome-wide association study; Pleiotropy; Quantitative trait locus; Genetic association; Proteome; Expression quantitative trait loci; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004078642,0.0009464353,0.001465956,0.002234789,0.0005062314,0.001381334,0.0007800363,0.0007273413,0.003844384],"category_scores_gemma":[0.004235678,0.0003600111,0.00157443,0.002157237,0.0004398958,0.0005014082,0.001254161,0.00102524,0.001101309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004932915,"about_ca_system_score_gemma":0.001407056,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002244776,"about_ca_topic_score_gemma":0.003864,"domain_scores_codex":[0.9982365,0.0005885364,0.00008068591,0.000542378,0.0004088501,0.0001429182],"domain_scores_gemma":[0.9982415,0.0007555568,0.0003447424,0.000207433,0.0001928805,0.000257802],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007240111,0.0008899663,0.3042849,0.001649763,0.007600538,0.001615934,0.0005523195,0.008113402,0.4226508,0.006483633,0.02268845,0.2162302],"study_design_scores_gemma":[0.00182983,0.004243025,0.7092893,0.0003112863,0.008153555,0.003909858,0.0004965005,0.1259844,0.06558808,0.01794321,0.06194164,0.0003093358],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.772062,0.005923627,0.1806205,0.002637123,0.0005448009,0.0007140088,0.02856223,0.003360216,0.005575429],"genre_scores_gemma":[0.8308777,0.001112474,0.1471484,0.001341883,0.0003382772,0.0005848022,0.01529771,0.0005219162,0.002776839],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004078642,"threshold_uncertainty_score":0.02157021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0475058302444508,"score_gpt":0.3569189423577517,"score_spread":0.3094131121133009,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}