{"id":"W4415791671","doi":"10.1161/circ.152.suppl_3.4370209","title":"Abstract 4370209: PROLONGED PROLIFERATION OF EARLY-STAGE HUMAN PLURIPOTENT STEM CELL-DERIVED VENTRICULAR CARDIOMYOCYTES REDUCES PACEMAKING FUNCTION WHILE PROMOTING MATURATION","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Stemcell Technologies","funders":"","keywords":"Induced pluripotent stem cell; Gene expression; Cell growth; Gene; Cell; Stem cell; Electrophysiology; Beat (acoustics); Myocyte","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001238504,0.0003492175,0.0003822376,0.0001767576,0.0001382131,0.0002487354,0.0002156891,0.000364325,0.006723884],"category_scores_gemma":[0.00008846727,0.0001029872,0.0002746489,0.0001806179,0.0002215556,0.0001535669,0.0001894885,0.0006378723,0.001016159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001762693,"about_ca_system_score_gemma":0.0003118645,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003265397,"about_ca_topic_score_gemma":0.0003316781,"domain_scores_codex":[0.9998165,0.00001307169,0.00002170113,0.0000406223,0.00008138455,0.00002680258],"domain_scores_gemma":[0.9999036,0.00001878752,0.00002621789,0.000008022746,0.00001651868,0.00002688592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002138874,0.00003964368,0.0001650485,0.00009792284,0.00000666957,0.00005526851,0.000007598539,0.00003215211,0.9961653,0.00005113047,0.0002571689,0.002908347],"study_design_scores_gemma":[0.00004022552,0.0007877841,0.006242283,0.00001783129,0.00002986748,0.0002774815,0.00002231746,0.0002937871,0.9882357,0.00003933145,0.004008869,0.000004514151],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9802204,0.004191763,0.004507512,0.000356578,0.0003002344,0.0001004647,0.003761711,0.0003597073,0.0062017],"genre_scores_gemma":[0.9638665,0.002800953,0.004214689,0.0003403341,0.0001209125,0.0002643295,0.006064971,0.00008796003,0.02223933],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006723884,"threshold_uncertainty_score":0.0224936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01817568320278056,"score_gpt":0.2623600729612711,"score_spread":0.2441843897584905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}