{"id":"W4415792387","doi":"10.1161/circ.152.suppl_3.4368295","title":"Abstract 4368295: Acoramidis Reduces All-Cause Mortality and First Cardiovascular Hospitalization in Patients with Variant Transthyretin Amyloid Cardiomyopathy: Results From the ATTRibute-CM Study","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Amyloidosis: Diagnosis, Treatment, Outcomes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Transthyretin; Randomization; Amyloidosis; Proportional hazards model; Amyloid (mycology); Randomized controlled trial; Cardiomyopathy; Confidence interval; Genotype","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001685088,0.0007527876,0.001735084,0.0002736303,0.0002360052,0.0008695501,0.0004877922,0.001108489,0.003468795],"category_scores_gemma":[0.001768507,0.0002515645,0.002614086,0.0003998032,0.0003248667,0.0004616803,0.0003559729,0.001496388,0.0004745751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003164631,"about_ca_system_score_gemma":0.000567975,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007073221,"about_ca_topic_score_gemma":0.001833838,"domain_scores_codex":[0.9993761,0.0003279344,0.00005668265,0.00008947863,0.00009914521,0.00005071226],"domain_scores_gemma":[0.9986412,0.0003684916,0.0004226188,0.0001263841,0.0001578976,0.0002834286],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8217001,0.01156654,0.05800121,0.002300262,0.01009595,0.0001513065,0.0001561269,0.0009980442,0.008454808,0.0002297685,0.004644722,0.08170124],"study_design_scores_gemma":[0.52412,0.1633844,0.2927586,0.0003466748,0.01039336,0.0004045003,0.0001641134,0.001948805,0.002316573,0.0006088645,0.003462966,0.00009111214],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884553,0.006505765,0.0002051375,0.0005343619,0.0001387423,0.0003327874,0.002253192,0.00005261906,0.001522205],"genre_scores_gemma":[0.9928064,0.00226248,0.0005361828,0.0005849176,0.0003812234,0.000243584,0.002314383,0.000009459164,0.0008613036],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003468795,"threshold_uncertainty_score":0.01160425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01858619332578273,"score_gpt":0.2548006083746273,"score_spread":0.2362144150488446,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}