{"id":"W4415792861","doi":"10.1161/circ.152.suppl_3.4343799","title":"Abstract 4343799: Genetically informed drug targeting of ryanodine receptor type 2 identifies new precision therapeutic candidates for catecholaminergic polymorphic ventricular tachycardia","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Catecholaminergic polymorphic ventricular tachycardia; Ryanodine receptor 2; Ventricular tachycardia; Population; Ryanodine receptor; Sudden death; Calcium in biology; Sudden cardiac death","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002337889,0.0004749815,0.0006547481,0.000296583,0.000140518,0.0005402412,0.0003292145,0.0003865481,0.005975474],"category_scores_gemma":[0.0001903173,0.0001511438,0.0004899792,0.0002740387,0.000159952,0.0002757785,0.0003330015,0.0005754511,0.00115253],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002987803,"about_ca_system_score_gemma":0.0003777461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000501734,"about_ca_topic_score_gemma":0.001112715,"domain_scores_codex":[0.9999044,0.00001155118,0.000004573651,0.00001924211,0.00004521063,0.00001513392],"domain_scores_gemma":[0.9999454,0.00001179783,0.00001583645,0.000005644813,0.00001098763,0.00001034873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0006899533,0.0002532118,0.001273279,0.000458134,0.00007601181,0.0004413886,0.00003690052,0.007689891,0.9188865,0.002345857,0.002887198,0.06496166],"study_design_scores_gemma":[0.001171823,0.01000264,0.01555028,0.0001668691,0.0006307459,0.003678014,0.00008961424,0.05414877,0.8367351,0.00293275,0.07478124,0.0001122879],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8935089,0.01539325,0.05171417,0.001294829,0.0002776766,0.0006098953,0.00696513,0.00260342,0.02763273],"genre_scores_gemma":[0.9265125,0.008565325,0.04380663,0.000513519,0.00006287824,0.0003079131,0.005521737,0.0002628995,0.01444661],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005975474,"threshold_uncertainty_score":0.01998997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01067311045173711,"score_gpt":0.2749696960776281,"score_spread":0.264296585625891,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}