{"id":"W4415792934","doi":"10.1161/circ.152.suppl_3.4366483","title":"Abstract 4366483: Multi-omic Characterization of Clonal Hematopoiesis of Indeterminate Potential (CHIP) in the ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) Trials Biorepository","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"DNA methylation; Transcriptome; Methylation; DNA microarray; Ischemia; Gene; Haematopoiesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.02118681,0.0006507089,0.001350974,0.0009115739,0.0006204897,0.001942076,0.001038838,0.000895648,0.01546829],"category_scores_gemma":[0.02384836,0.0003301074,0.001557417,0.001640235,0.0007257115,0.0007144469,0.001391551,0.001129968,0.001636204],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005134871,"about_ca_system_score_gemma":0.001811988,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004716019,"about_ca_topic_score_gemma":0.0007348579,"domain_scores_codex":[0.9892175,0.007774385,0.0006688826,0.0009191933,0.001054864,0.0003652158],"domain_scores_gemma":[0.9801372,0.009772921,0.004818439,0.002322749,0.001666504,0.001282219],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.1871236,0.002249901,0.3870557,0.01177888,0.01871804,0.0005936053,0.0008992436,0.00285869,0.03771815,0.009462886,0.08362614,0.2579152],"study_design_scores_gemma":[0.0342228,0.03146777,0.758628,0.002864603,0.01815309,0.002093995,0.0005413756,0.004999224,0.01638051,0.01601446,0.1144038,0.0002303709],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7420641,0.03129279,0.0485361,0.009635624,0.001502887,0.01074169,0.1267352,0.0009573395,0.02853435],"genre_scores_gemma":[0.8977862,0.002750734,0.03171315,0.003700886,0.0009775669,0.01860357,0.03868495,0.0003013191,0.005481533],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02118681,"threshold_uncertainty_score":0.1120479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04993028063688332,"score_gpt":0.3336161272609259,"score_spread":0.2836858466240426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}