{"id":"W4415793439","doi":"10.1161/circ.152.suppl_3.4366887","title":"Abstract 4366887: HS235, a Novel Activin Signaling Inhibitor, is Highly Efficacious in Preclinical Models of Pulmonary Hypertension and Heart Failure","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Micropharma (Canada)","funders":"","keywords":"Pulmonary hypertension; Heart failure; Homeostasis; Receptor; Bone morphogenetic protein; Activin receptor; Adipose tissue; Biomarker; Lymphangiogenesis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003494199,0.001025079,0.000856657,0.0006981758,0.000247536,0.0004639163,0.0004454661,0.0006617072,0.006123048],"category_scores_gemma":[0.0001279103,0.0002636427,0.000457883,0.0003258435,0.0003765815,0.000421595,0.0001810297,0.001600053,0.001217587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000304133,"about_ca_system_score_gemma":0.0007099359,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006488368,"about_ca_topic_score_gemma":0.001271876,"domain_scores_codex":[0.9998139,0.0000285376,0.00001525435,0.00002776658,0.00006112275,0.00005347877],"domain_scores_gemma":[0.9998772,0.000008734579,0.00002920166,0.00000753176,0.00001391847,0.00006333955],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0110548,0.003023995,0.0004593531,0.0007083188,0.0001713689,0.0003828863,0.00007020411,0.000804933,0.9179673,0.001050038,0.004886745,0.05942016],"study_design_scores_gemma":[0.007042464,0.05633824,0.01234122,0.00009715949,0.000396673,0.002068073,0.00009216351,0.003185227,0.8857905,0.0003523748,0.03222619,0.00006959388],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9599047,0.01265505,0.005992753,0.001032313,0.0005540631,0.0006204727,0.003587508,0.001731528,0.01392162],"genre_scores_gemma":[0.966444,0.007003396,0.005953162,0.0004560419,0.000225797,0.0003713364,0.004528383,0.00008844059,0.01492944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006123048,"threshold_uncertainty_score":0.02048361,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02518135786203938,"score_gpt":0.2760453288702621,"score_spread":0.2508639710082227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}