{"id":"W4415793620","doi":"10.1161/circ.152.suppl_3.4369077","title":"Abstract 4369077: Postoperative Inflammation Promotes HDL Dysfunction, Disrupting Reverse Cholesterol Transport and Driving Rapid Atherosclerotic Plaque Destabilization","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Inflammation biomarkers and pathways","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Reverse cholesterol transport; Inflammation; Cholesterol; Foam cell; Efflux; Fibrous cap; Macrophage; In vivo; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002674377,0.0005241727,0.0006394808,0.0001946473,0.0002788172,0.0003905568,0.0002094018,0.0004605912,0.007758847],"category_scores_gemma":[0.0001032957,0.000168103,0.0004224984,0.0002027747,0.0004221638,0.0002076889,0.0002760429,0.0009377112,0.001937532],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002087169,"about_ca_system_score_gemma":0.0005105549,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003313766,"about_ca_topic_score_gemma":0.0003665307,"domain_scores_codex":[0.999811,0.00002497604,0.00001964974,0.00003894283,0.00004006475,0.00006540288],"domain_scores_gemma":[0.9998584,0.00001541441,0.00002728532,0.00001431302,0.00001812764,0.00006648491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006267292,0.0007553142,0.003274404,0.0002417163,0.00003894056,0.000646481,0.00003454918,0.00003751558,0.9812465,0.0001602294,0.001094512,0.006202422],"study_design_scores_gemma":[0.001623481,0.03573564,0.1290317,0.0001203627,0.000347055,0.006400696,0.0005104994,0.001247186,0.8079117,0.0004771072,0.01655272,0.00004193925],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940739,0.001385943,0.0008612502,0.0004412764,0.0002440504,0.00007843159,0.001031486,0.00007224478,0.001811378],"genre_scores_gemma":[0.9854712,0.001653617,0.001438341,0.0006430382,0.0002502817,0.0002463143,0.002512781,0.00003823289,0.007746187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007758847,"threshold_uncertainty_score":0.02595598,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138487520082077,"score_gpt":0.2213466214600806,"score_spread":0.2099617462592598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}