{"id":"W4415793620","doi":"10.1161/circ.152.suppl_3.4369077","title":"Abstract 4369077: Postoperative Inflammation Promotes HDL Dysfunction, Disrupting Reverse Cholesterol Transport and Driving Rapid Atherosclerotic Plaque Destabilization","year":2025,"lang":"en","type":"article","venue":"Circulation","topic":"Inflammation biomarkers and pathways","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"","keywords":"Reverse cholesterol transport; Inflammation; Cholesterol; Foam cell; Efflux; Fibrous cap; Macrophage; In vivo; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003998868,0.0001735507,0.0001747697,0.0001655107,0.000418562,0.00004377285,0.0000570262,0.0002458742,0.0001516842],"category_scores_gemma":[0.0001088805,0.0001730699,0.00004986103,0.0002028202,0.00009444373,0.0004784831,0.00001433574,0.0001531873,0.00003170812],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008119825,"about_ca_system_score_gemma":0.00005705122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000379443,"about_ca_topic_score_gemma":0.00009119566,"domain_scores_codex":[0.9989038,0.000122057,0.0004381276,0.0003064306,0.00004590509,0.0001836483],"domain_scores_gemma":[0.9993672,0.00009413485,0.0001876171,0.0001696384,0.0001634002,0.00001795628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00005268698,0.00003162869,0.2312929,0.00009664329,0.00006371395,9.075104e-7,0.002599794,0.0004589288,0.7396692,0.001501586,0.00003627975,0.02419576],"study_design_scores_gemma":[0.0010578,0.00002618479,0.9624616,0.0002259565,0.00004750643,0.00001141221,0.0003861928,0.0006451436,0.0338194,0.0002642917,0.0008686009,0.0001858902],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850956,0.0001365318,0.01233054,0.0004073848,0.0003767125,0.0006597685,0.000006587578,0.0001121056,0.0008748165],"genre_scores_gemma":[0.9991605,0.0000276151,0.00008631717,0.00006819565,0.00003059796,0.00004046598,0.0004636357,0.00001338073,0.0001092459],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7311687,"threshold_uncertainty_score":0.7057585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01138487520082077,"score_gpt":0.2213466214600806,"score_spread":0.2099617462592598,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}